RNPA1000

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RNPA1000 是一种有效的、特异性的金黄色葡萄球菌 RnpA RNA 降解活性小分子抑制剂 (IC50=100-125 uM)。

RNPA1000 is a potent, specific small molecule inhibitor of S. aureus RnpA RNA degradation activity (IC50=100-125 uM), limits S. aureus mRNA turnover and growth; does not affect the activity of the E. coli RNase HI, RNase A, RNase I or in-house purified S. aureus RNase J1 at 750 uM; also limits growth of other important Gram-positive bacterial pathogens, exhibits antimicrobial efficacy against biofilm associated S. aureus (S. aureus MRSA USA100 strain MIC=26 ug/mL) and protects against the S. aureus pathogenesis in an animal model of infection.

RNPA1000 displays antimicrobial activity toward Gram-positive bacteria and little or no toxicity toward human cells. RNPA1000 limits S. aureus mRNA turnover and growth. RNPA1000 also limits growth of other important Gram-positive bacterial pathogens, exhibits antimicrobial efficacy against biofilm associated S. aureus and protects against the S. aureus pathogenesis in an animal model of infection.RNPA1000 (IC50=?100-125 μM), does not affect the activity of the commercially available E. coli RNase HI, RNase A, RNase I or in-house purified S. aureus RNase J1 at any concentration tested (0-750 μM), but does mildly inhibit E. coli RNase III activity (IC50=?500-750 μM).

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RNPA-1000

GPCR/G Protein

Antibacterial

Antibacterial

Infection

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359600-10-5

464.3113

C23H18BrN3O3

>98% (HPLC)

10 mM in DMSO

CC1=CC(=C(N1C2=CC=C(C=C2)C(=O)O)C)C=C(C#N)C(=O)NC3=CC(=CC=C3)Br

Benzoic acid, 4-[3-[3-[(3-bromophenyl)amino]-2-cyano-3-oxo-1-propen-1-yl]-2,5-dimethyl-1H-pyrrol-1-yl]-

(-20℃)

With Ice Pack

≥ 2 years