Cyclo-L-Trp-L-Trp

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cyclo-L-Trp-L-Trp 是一种广谱抗真菌剂。它还诱导组蛋白高度乙酰化。

Cyclo-L-Trp-L-Trp is a broad-spectrum antifungal. It also induces a high degree of acetylation of histones.(In Vitro):Two novel cyclic hexapeptides designated actinosynneptides A (1) and B (2), together with three tryptophan containing diketopiperazines, namely cyclo(L-Trp-L-Trp) (3), cyclo(L-Trp-N-MeL-Trp) (4), and cyclo(N-MeL-Trp-N-MeL-Trp) (5), were isolated from the culture of the genetically engineered strain HGF052::asm18 derived from Actinosynnema pretiosum ATCC31565. Their structures were elucidated on the basis of spectroscopic analyses and single-crystal X-ray diffractions. Compound 1 is the first example of 3-amino-6-hydroxy-2-piperidone-containing cyclic peptides, and 1 and 2 showed moderate cytotoxic activities against HeLa and PC3 cell lines.

Cyclo(L-Trp-L-Trp) can inhibit A. baumannii (MICs=12.5-25 μg/mL), as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus (MICs=12.5-50 μg/mL).

——

——

GPCR/G Protein

Antibacterial

PEGs

——

——

20829-55-4

372.428

C22H20N4O2

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (335.64 mM)

O=C1N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H]1Cc1c[nH]c2ccccc12

——

(-20℃)

With Ice Pack

≥ 2 years