Sulfatinib ( HMPL-012;Surufatinib;HMPL012 )

产品货号. M11232 CAS No. 1308672-74-3

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Datasheet

HNMR

HPLC

MSDS

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产品名称

Sulfatinib
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Sulfatinib (HMPL-012) is a potent, multi-targeted tyrosine kinase inhibitor of VEGFR-1/2/3, FGFR1, CSF1R with IC50 of 2/24/1 nM, 15 nM, 4 nM, respectively.
产品描述

Sulfatinib (HMPL-012) is a potent, multi-targeted tyrosine kinase inhibitor of VEGFR-1/2/3, FGFR1, CSF1R with IC50 of 2/24/1 nM, 15 nM, 4 nM, respectively; also potently inhibits TrkB and FLT-3 with IC50 of 41 and 67 nM, shows little to no activity against other 278 other kinases (IC50>150 nM); targets tumor angiogenesis and immune modulation, exhibits an acceptable safety profile and encouraging antitumor activity in clinical investigations.Brain Cancer Phase 3 Clinical
同义词

HMPL-012;Surufatinib;HMPL012
通路

Angiogenesis
靶点

VEGFR
受体

VEGFR
研究领域

Cancer
适应症

Brain Cancer

CAS Number

1308672-74-3
分子量

480.58
分子式

C24H28N6O3S
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 30 mg/mL
SMILES

CC1=CC2=C(N1)C=CC(OC3=NC(NC4=CC(CS(NCCN(C)C)(=O)=O)=CC=C4)=NC=C3)=C2
化学全称

Benzenemethanesulfonamide, N-[2-(dimethylamino)ethyl]-3-[[4-[(2-methyl-1H-indol-5-yl)oxy]-2-pyrimidinyl]amino]-

1. Xu JM, et al. Oncotarget. 2017 Jun 27;8(26):42076-42086.

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