Skepinone-L ( Skepinone-L )

产品货号. M17201 CAS No. 1221485-83-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Skepinone-L
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
产品描述

Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38α (IC50s = 5 nM) and p38β (97% inhibition at 1 μM).
同义词

Skepinone-L
通路

Metabolic Enzyme/Protease
靶点

Dehydrogenase
受体

p38α
研究领域

Inflammation/Immunology
适应症

——

CAS Number

1221485-83-1
分子量

425.42
分子式

C24H21F2NO4
纯度

98%
溶解度

DMSO : ≥ 50 mg/mL 117.53 mM; H2O : < 0.1 mg/mL
SMILES

c12c(C(=O)c3c(CC1)ccc(c3)OC[C@@H](CO)O)ccc(c2)Nc1c(cc(cc1)F)F
化学全称

2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one

1. Koeberle SC, et al. Nat Chem Biol. 2011, 8(2), 141-143.

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