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Simeprevir
CAS No. 923604-59-5
Simeprevir ( TMC-435;TMC435;TMC435350;TMC-435350 )
产品货号. M16618 CAS No. 923604-59-5
A potent, orally available inhibitor of HCV NS3/4A protease with Ki of 0.36 nM, replicon EC50 of 7.8 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥243 | 有现货 |
|
| 5MG | ￥373 | 有现货 |
|
| 10MG | ￥494 | 有现货 |
|
| 25MG | ￥689 | 有现货 |
|
| 50MG | ￥1021 | 有现货 |
|
| 100MG | ￥1604 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Simeprevir
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, orally available inhibitor of HCV NS3/4A protease with Ki of 0.36 nM, replicon EC50 of 7.8 nM.
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产品描述A potent, orally available inhibitor of HCV NS3/4A protease with Ki of 0.36 nM, replicon EC50 of 7.8 nM; inhibits NS3/4A proteases of genotypes 1a and 1b with Ki of 0.5 and 0.4 nM, shows synergistic effect with α-Interferon and an NS5B inhibitor in the replicon model and additive with ribavirin; exerts favorable pharmacokinetic profile and antiviral activity in vivo.HCV Infection Approved
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同义词TMC-435;TMC435;TMC435350;TMC-435350
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通路Microbiology/Virology
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靶点HCV
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受体HCV
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研究领域Infection
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适应症HCV Infection
化学信息
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CAS Number923604-59-5
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分子量749.94
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分子式C38H47N5O7S2
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCC1=C(C=CC2=C1N=C(C=C2OC3CC4C(C3)C(=O)N(CCCCC=CC5CC5(NC4=O)C(=O)NS(=O)(=O)C6CC6)C)C7=NC(=CS7)C(C)C)OC
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化学全称Cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide, N-(cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-, (2R,3aR,1
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Raboisson P, et al. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8.
2. Lin TI, et al. Antimicrob Agents Chemother. 2009 Apr;53(4):1377-85.
3. Lenz O, et al. Antimicrob Agents Chemother. 2010 May;54(5):1878-87.
2. Lin TI, et al. Antimicrob Agents Chemother. 2009 Apr;53(4):1377-85.
3. Lenz O, et al. Antimicrob Agents Chemother. 2010 May;54(5):1878-87.
产品手册
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A potent, orally available inhibitor of HCV NS3/4A protease with Ki of 0.36 nM, replicon EC50 of 7.8 nM.
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