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Salicoside

CAS No. 138-52-3

Salicoside ( NSC 5751 | D-(-)-Salicin )

产品货号. M11602 CAS No. 138-52-3

水杨苷是一种从柳树皮中提取的酚 β-糖苷,具有抗炎作用。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
50MG ¥335 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Salicoside
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    水杨苷是一种从柳树皮中提取的酚 β-糖苷,具有抗炎作用。
  • 产品描述
    Salicin is a phenol β-glycosid produced from willow bark that shows anti-inflammatory effects.(In Vitro):Significant down regulation of PGE2, the enzymatic product of COX2, to 76% in lysate and 70% in supernatant is observed with Salicin 10 μM treatment in COLO cells when compare to the COLO control. This is accompanied with a minimal COX1 inhibition to 91% of the CCD control on the genetic level. Treatment with Salicin 1 μM decreases colon cancer cell proliferation rates from 144% to 113% at 24 hours and 187% to 130% at 48 hours, with 10 μM decreasing proliferation rates to 108% at 24 hours and 119% at 48 hours. The concentrations of TNF-α, IL-1β and IL-6 of LPS-induced cells pretreated with 0.07, 0.14 and 0.28 μM Salicin are significant reduced compare with LPS group.(In Vivo):Salicin (D(-)-Salicin) (35, 70, 140 μM) markedly inhibits the LPS-induced pathological changes. MPO activity in LPS-induced lung tissue is significantly increased compare with control group. However, Salicin (35, 70, 140 μM) markedly inhibits this change. Pretreatment with Salicin inhibits LPS-induced activation of JNK, ERK, p38/MAPK and p65 in a dose-dependent manner.
  • 体外实验
    Significant down regulation of PGE2, the enzymatic product of COX2, to 76% in lysate and 70% in supernatant is observed with Salicin 10 μM treatment in COLO cells when compare to the COLO control. This is accompanied with a minimal COX1 inhibition to 91% of the CCD control on the genetic level. Treatment with Salicin 1 μM decreases colon cancer cell proliferation rates from 144% to 113% at 24 hours and 187% to 130% at 48 hours, with 10 μM decreasing proliferation rates to 108% at 24 hours and 119% at 48 hours. The concentrations of TNF-α, IL-1β and IL-6 of LPS-induced cells pretreated with 0.07, 0.14 and 0.28 μM Salicin are significant reduced compare with LPS group.
  • 体内实验
    Salicin (D(-)-Salicin) (35, 70, 140 μM) markedly inhibits the LPS-induced pathological changes. MPO activity in LPS-induced lung tissue is significantly increased compare with control group. However,Salicin (35, 70, 140 μM) markedly inhibits this change. Pretreatment withSalicin inhibits LPS-induced activation of JNK, ERK, p38/MAPK and p65 in a dose-dependent manner.
  • 同义词
    NSC 5751 | D-(-)-Salicin
  • 通路
    Chromatin/Epigenetic
  • 靶点
    COX
  • 受体
    COX
  • 研究领域
    Other Indications
  • 适应症
    ——

化学信息

  • CAS Number
    138-52-3
  • 分子量
    286.28
  • 分子式
    C13H18O7
  • 纯度
    >98% (HPLC)
  • 溶解度
    Water: 24 mg/mL (83.83 mM); DMSO: 57 mg/mL (199.1 mM)
  • SMILES
    O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=CC=C2CO
  • 化学全称
    alpha-Hydroxy-o-tolyl beta-D-glucopyranoside

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Wei W, et al. J Asian Nat Prod Res. 2015 Apr 23:1-6.
产品手册
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