
Salicoside
CAS No. 138-52-3
Salicoside ( NSC 5751 | D-(-)-Salicin )
产品货号. M11602 CAS No. 138-52-3
水杨苷是一种从柳树皮中提取的酚 β-糖苷,具有抗炎作用。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
50MG | ¥335 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Salicoside
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述水杨苷是一种从柳树皮中提取的酚 β-糖苷,具有抗炎作用。
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产品描述Salicin is a phenol β-glycosid produced from willow bark that shows anti-inflammatory effects.(In Vitro):Significant down regulation of PGE2, the enzymatic product of COX2, to 76% in lysate and 70% in supernatant is observed with Salicin 10 μM treatment in COLO cells when compare to the COLO control. This is accompanied with a minimal COX1 inhibition to 91% of the CCD control on the genetic level. Treatment with Salicin 1 μM decreases colon cancer cell proliferation rates from 144% to 113% at 24 hours and 187% to 130% at 48 hours, with 10 μM decreasing proliferation rates to 108% at 24 hours and 119% at 48 hours. The concentrations of TNF-α, IL-1β and IL-6 of LPS-induced cells pretreated with 0.07, 0.14 and 0.28 μM Salicin are significant reduced compare with LPS group.(In Vivo):Salicin (D(-)-Salicin) (35, 70, 140 μM) markedly inhibits the LPS-induced pathological changes. MPO activity in LPS-induced lung tissue is significantly increased compare with control group. However, Salicin (35, 70, 140 μM) markedly inhibits this change. Pretreatment with Salicin inhibits LPS-induced activation of JNK, ERK, p38/MAPK and p65 in a dose-dependent manner.
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体外实验Significant down regulation of PGE2, the enzymatic product of COX2, to 76% in lysate and 70% in supernatant is observed with Salicin 10 μM treatment in COLO cells when compare to the COLO control. This is accompanied with a minimal COX1 inhibition to 91% of the CCD control on the genetic level. Treatment with Salicin 1 μM decreases colon cancer cell proliferation rates from 144% to 113% at 24 hours and 187% to 130% at 48 hours, with 10 μM decreasing proliferation rates to 108% at 24 hours and 119% at 48 hours. The concentrations of TNF-α, IL-1β and IL-6 of LPS-induced cells pretreated with 0.07, 0.14 and 0.28 μM Salicin are significant reduced compare with LPS group.
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体内实验Salicin (D(-)-Salicin) (35, 70, 140 μM) markedly inhibits the LPS-induced pathological changes. MPO activity in LPS-induced lung tissue is significantly increased compare with control group. However,Salicin (35, 70, 140 μM) markedly inhibits this change. Pretreatment withSalicin inhibits LPS-induced activation of JNK, ERK, p38/MAPK and p65 in a dose-dependent manner.
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同义词NSC 5751 | D-(-)-Salicin
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通路Chromatin/Epigenetic
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靶点COX
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受体COX
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研究领域Other Indications
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适应症——
化学信息
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CAS Number138-52-3
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分子量286.28
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分子式C13H18O7
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纯度>98% (HPLC)
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溶解度Water: 24 mg/mL (83.83 mM); DMSO: 57 mg/mL (199.1 mM)
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SMILESO[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=CC=C2CO
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化学全称alpha-Hydroxy-o-tolyl beta-D-glucopyranoside
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Wei W, et al. J Asian Nat Prod Res. 2015 Apr 23:1-6.
产品手册




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