Phenacetin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Phenacetin (Acetophenetidin) 是一种非阿片类解热化合物，可用于缓解疼痛的研究。Phenacetin 是一种选择性的 COX-3 抑制剂。Phenacetin 能作为人肝微粒体和大鼠体内 CYP1A2 的探针。

Phenacetin is a non-opioid analgesic without anti-inflammatory properties. Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. Phenacetin is an antipyretic, acting on the brain to decrease the temperature set point. Phenacetin is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.(In Vitro):Phenacetin shows inhibitory activity for COX-3 with an IC50 value of 102 μM in insect cells .Phenacetin is a substrate widely used as an in vitro and in vivo probe to measure the activity of CYP1A2, because the metabolism of phenacetin to acetaminophen is thought to be a selective CYP1A2-mediated reaction.(In Vivo):Phenacetin exhibits elimination half-life (rat 2.06 h) and Cmax (6,728.3 μg/L) following oral administration (rat 20 mg/kg).

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p-Acetophenetidide | 4′-Ethoxyacetanilide | NSC 7651

Chromatin/Epigenetic

COX

COX-1

Inflammation/Immunology

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62-44-2

179.22

C10H13NO2

>98% (HPLC)

Ethanol: 36 mg/mL (200.87 mM); DMSO: 36 mg/mL (200.87 mM)

CC(NC1=CC=C(OCC)C=C1)=O

N-(4-Ethoxyphenyl)acetamide

(-20℃)

With Ice Pack

≥ 2 years