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SGI-1776
CAS No. 1025065-69-3
SGI-1776 ( SGI 1776 | SGI1776 )
产品货号. M10114 CAS No. 1025065-69-3
SGI-1776 是一种有效的、选择性的、口服活性的 Pim 激酶抑制剂，对 Pim1、Pim2 和 Pim3 的 IC50 分别为 7、363 和 69 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥389 | 有现货 |
|
| 5MG | ￥794 | 有现货 |
|
| 10MG | ￥1418 | 有现货 |
|
| 25MG | ￥2592 | 有现货 |
|
| 50MG | ￥3734 | 有现货 |
|
| 100MG | ￥4787 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称SGI-1776
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SGI-1776 是一种有效的、选择性的、口服活性的 Pim 激酶抑制剂，对 Pim1、Pim2 和 Pim3 的 IC50 分别为 7、363 和 69 nM。
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产品描述SGI-1776 is a potent, selective, orally active Pim kinase inhibitor with IC50 of 7, 363 and 69 nM for Pim1, Pim2 and Pim3, respectively; exhibits promising selectivity against a panel of >300 kinases, shows inhibitory activity against two other kinases: Flt-3 (IC50=44 nM) and Haspin (IC50=34 nM); reduces cell viability of androgen-independent prostate cancer cell lines with IC50 of 2-4 uM, causes cell cycle arrest and caspase-dependent apoptosis in prostate cancer cells, marginally sensitizes prostate cancer cells to taxane-based therapeutics by inhibiting MDR1 activity and inducing apoptosis; shows efficacy in xenograft model bearing MV-4-11 tumors.Prostate Cancer Phase 1 Clinical.
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体外实验——
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体内实验——
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同义词SGI 1776 | SGI1776
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通路JAK/STAT Signaling
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靶点Pim
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受体FLT3|Pim1|Pim2|Pim3
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研究领域Cancer
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适应症Prostate Cancer
化学信息
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CAS Number1025065-69-3
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分子量405.42
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分子式C20H22F3N5O
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESFC(F)(F)OC1=CC=C(C2=CN=C3C=CC(NCC4CCN(C)CC4)=NN32)C=C1
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化学全称Imidazo[1,2-b]pyridazin-6-amine, N-[(1-methyl-4-piperidinyl)methyl]-3-[3-(trifluoromethoxy)phenyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Chen LS, et al. Blood. 2009 Nov 5;114(19):4150-7.
2. Chen LS, et al. Blood. 2011 Jul 21;118(3):693-702.
3. Chang M, et al. Mol Cancer Ther. 2010 Sep;9(9):2478-87.
4. Mumenthaler SM, et al. Mol Cancer Ther. 2009 Oct;8(10):2882-93.
产品手册
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