1-phenoxazin-10-ylethanone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

1-phenoxazin-10-ylethanone 是一种 Pim-2 抑制剂。 1-phenoxazin-10-ylethanone 诱导三阴性人类乳腺癌细胞凋亡和自噬性细胞死亡。

1-phenoxazin-10-ylethanone is a Pim-2 inhibitor. 1-phenoxazin-10-ylethanone induces apoptosis and autophagic cell death in triple-negative human breast cancer.

Western Blot Analysis Cell Line:MDA-MB-231 cell line Concentration:300 and 460 nmol/L Incubation Time:12, 24, 36 and 48 hours Result:Time-dependently increased LC3-II and Beclin-1 and induced p62 degradation in MDA-MB-231 cells. Increased the level of Bax. Decreased the level of Bcl-2, and Pim-2 and Pim-2 phosphorylation. Activated caspase-9 and caspase-3.

Animal Model:BALB/c female nude mice with MDA-MB-231 cells injection Dosage:40 mg/kg Administration:Oral administration; 40 mg/kg, once daily for 10 days Result:Significantly inhibited tumor growth with an obvious decreasing of the body, liver, spleen and kidney weights of the mice.

10-acetylphenoxazine | N-Acetylphenoxazine | HJ-PI01

JAK/STAT Signaling

Pim

histone acetyltransferase

——

——

6192-43-4

225.247

C14H11NO2

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (221.99 mM)

CC(=O)N1c2ccccc2Oc2ccccc12

——

(-20℃)

With Ice Pack

≥ 2 years