SD-1029 ( SD1029 | NSC 371488 )

产品货号. M10623 CAS No. 118372-34-2

SD-1029 (NSC 371488) 是 Stat3 激活的有效抑制剂。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

SD-1029
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SD-1029 (NSC 371488) 是 Stat3 激活的有效抑制剂。
产品描述

SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation, suppresses EGFP-Stat3 nuclear translocation at 10 uM in both BHK-21 and U2-OS cells; inhibits Stat3-mediated antiapoptotic protein expression (Bcl-XL, MCL-1, and survivin), and suppresses phosphotyrosine levels of JAK2; inhibits IL-6 or oncostatin-induced Stat3 nuclear translocation at micromolar range, enhances apoptosis induced by paclitaxel in human cancer cells.
体外实验

SD-1029 (10 μM) inhibits EGFP-Stat3 nuclear translocation in BHK-21 and U-2OS cells. SD-1029 (5 and 10 μM; 24 hours) inhibits cell growth and induces apoptosis in OVCAR8TR ovarian cancer cells.SD-1029 (10 μM; 24 hours) suppresses p-Stat3 levels in human breast and ovarian cancer cell lines.SD-1029 inhibits not only JAK2 phosphorylation, but also the phosphorylation of STAT1 and STAT3. SD-1029 strongly inhibits Tyk2 phosphorylation, implicating both JAK2 and Tyk2 as upstream requirements for IL-23-induced IL-23R expression. Cell Proliferation Assay Cell Line:OVCAR8TR ovarian cancer cells Concentration:5 and 10 μM Incubation Time:24 hours Result:Down-regulated cell proliferation, and induced apoptotic cell death.Treatment resulted in a marked, 20-fold induction of apoptosis in the OVCAR8TR cells that express constitutively activated Stat3.Western Blot Analysis Cell Line:MDA-MB-468 and MDA435 (breast cancer), OV1063 (ovarian cancer), and the paclitaxel-resistant ovarian cancer daughter lines, SKOV-3TR and OVCAR8TR.Concentration:10 μM Incubation Time:24 hours Result:Led to reduced levels of pStat3.
体内实验

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同义词

SD1029 | NSC 371488
通路

JAK/STAT Signaling
靶点

STAT
受体

STAT
研究领域

Cancer
适应症

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化学信息

CAS Number

118372-34-2
分子量

639.3
分子式

C25H30Cl2N2O3 ? 2HBr
纯度

>98% (HPLC)
溶解度

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SMILES

O=C1C(C(C2=CC=C(Cl)C(Cl)=C2)C3=C(CCC(CN(C)C)C3=O)O4)=C4CCC1CN(C)C.[H]Br.[H]Br
化学全称

9-(3,4-dichlorophenyl)-2,7-bis[(dimethylamino)methyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione, dihydrobromide

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Duan Z, et al. Clin Cancer Res. 2006 Nov 15;12(22):6844-52. 2. Yang C, et al. Mol Cancer Ther. 2009 Sep;8(9):2597-605. 3. Che Mat NF, et al. J Interferon Cytokine Res. 2011 Apr;31(4):363-71.

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