Niclosamide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

氯硝柳胺 (BAY2353) 通过抑制 DNA 复制来治疗大多数绦虫感染。

Niclosamide(BAY2353) is used for the treatment of most tapeworm infections by inhibiting DNA replication.

Cell Viability Assay Cell Line:BD140A, SW-13 and NCI-H295R cells Concentration:0.6 nM-46 μM Incubation Time:Result:Inhibited cellular proliferation in adrenocortical carcinoma cell lines with the IC50 of 0.12 μM, 0.15 μM, and 0.53 μM in BD140A, SW-13, and NCI-H295R, respectively.Cell Viability Assay Cell Line:Hela cells Concentration:0.05-5 μM Incubation Time:24 hours Result:Inhibited STAT3-mediated luciferase reporter activity with an IC50 of 0.25 μM.Cell Viability Assay Cell Line:Vero E6 cells Concentration:10 μM Incubation Time:2 days Result:Inhibited the synthesis of viral antigens of SARS-CoV in Vero E6 cells.

Animal Model:Nu+/Nu+ mice injected with NCI-H295R cells Dosage:100 mg/kg, 200 mg/kg Administration:Oral gavage; 100 mg/kg, 200 mg/kg; once a week; 8 weeks Result:Showed a 60%-80% inhibition in tumor growth, as compared to the control group.

NSC 178296

JAK/STAT Signaling

STAT

STAT3

Infection

——

50-65-7

327.12

C13H8Cl2N2O4

>98% (HPLC)

Ethanol: <1 mg/mL (<1 mM); Water: <1 mg/mL (<1 mM); DMSO: <1 mg/mL (<1 mM)

O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O

5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

(-20℃)

With Ice Pack

≥ 2 years