Corosolic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

科罗索酸具有抗血管生成活性，可以抑制由 angiopoietin-1 诱导的 FAK 信号传导。

Corosolic acid is a pentacyclic triterpene acid found in Lagerstroemia speciosa. It is similar in structure to ursolic acid, differing only in the fact that it has a 2-alpha-hydroxy attachment. Corosolic acid has numerous biological properties, including antidiabetic, anti-inflammatory, antiproliferative, and protein kinase C inhibition activity. However, there is a lack of clinical evidence to support these uses.

Apoptosis Analysis Cell Line:CT-26 cells Concentration:25?μM Incubation Time:12 and 24 h Result:Increased cleaved caspase-3 level.Increased cells in the sub-G1 population.Increased fluorescin-dUTP labeling DNA strand breaks.Western Blot Analysis Cell Line:HCT116 and SW480 cells Concentration:20 μM Incubation Time:0-24 h Result:Decreased the formation of NRG1-induced HER2/HER3 heterodimer.Inhibited the PI3K/Akt/PDE3B but not the ERK1/2 signaling pathway.

Animal Model:CT-26 allograft colon carcinoma mice modelDosage:5, 25?mg/kg/day Administration:Peritumor injection, 12 days Result:Reduced the tumor weight to 76.2% and 53.8% of the control group.Reduced blood and lymphatic vessel densities.Animal Model:high-fat fed miceDosage:10 mg/kg/day Administration:Supplemented in diet, 8 weeks Result:Inhibited hyperlipidemia, Improved insulin sensitivity and glucose intolerance. Inhibited inflammation in adipose tissues.Inhibited macrophage infiltrations into adipose tissue.

Glucosol

JAK/STAT Signaling

STAT

FAK

Cancer

——

4547-24-4

472.7

C30H48O4

>98% (HPLC)

DMSO : ≥ 50 mg/mL 105.78 mM; H2O : < 0.1 mg/mL

C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]3[C@@]4(C[C@H]([C@@H](C3(C)C)O)O)C)C)[C@@H]2[C@H]1C)C)C(=O)O

(2α,3β)-2,3-Dihydroxyurs-12-en-28-oic acid

(-20℃)

With Ice Pack

≥ 2 years