Rocilinostat ( ACY-1215 )

产品货号. M11280 CAS No. 1316214-52-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

Rocilinostat
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM in a cell-free assay.
产品描述

Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM in a cell-free assay. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2. Phase 2.
同义词

ACY-1215
通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

HDAC1; HDAC2; HDAC3; HDAC6; HDAC8
研究领域

Cancer
适应症

——

CAS Number

1316214-52-4
分子量

433.50
分子式

C24H27N5O3
纯度

>98%(HPLC)
溶解度

DMSO: 86 mg/mL (198.38 mM)
SMILES

O=C(C1=CN=C(N(C2=CC=CC=C2)C3=CC=CC=C3)N=C1)NCCCCCCC(NO)=O
化学全称

2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide

1.Santo L, et al. Blood, 2012, 119(11), 2579-2589.

计算器

产品手册

关联产品

Givinostat

Givinostat hydrochloride monohydrate is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
ACY-241

ACY-241, also known as Citarinostat, is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity.
Givinostat

Givinostat or gavinostat, aslo known as ITF2357, is a potent and orally active histone deacetylase inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities.