ACY-241 ( Citarinostat )

产品货号. M11281 CAS No. 1316215-12-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

ACY-241
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ACY-241, also known as Citarinostat, is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity.
产品描述

ACY-241, also known as Citarinostat, is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activity of HDACs; this results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This leads to the inhibition of tumor oncogene transcription, and the selective transcription of tumor suppressor genes, which inhibit tumor cell division and induce tumor cell apoptosis.
同义词

Citarinostat
通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

HDAC1; HDAC2; HDAC3; HDAC6; HDAC8
研究领域

Cancer
适应症

——

CAS Number

1316215-12-9
分子量

467.95
分子式

C24H26ClN5O3
纯度

>98%(HPLC)
溶解度

Soluble in DMSO
SMILES

ClC1=CC=CC=C1N(C2=CC=CC=C2)C3=NC=C(C=N3)C(NCCCCCCC(NO)=O)=O
化学全称

2-((2-chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide

1. Ruben N, et al. Blood. 2015, 126:3040;

计算器

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