R-59949
CAS No. 120166-69-0
R-59949 ( R59949;R 59949 )
产品货号. M10724 CAS No. 120166-69-0
A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥437 | 有现货 |
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5MG | ¥680 | 有现货 |
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10MG | ¥1199 | 有现货 |
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25MG | ¥2535 | 有现货 |
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50MG | ¥3969 | 有现货 |
|
100MG | ¥5978 | 有现货 |
|
500MG | ¥12393 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称R-59949
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets.
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产品描述A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets; markedly increases PKC activity in platelets stimulated with vasopressin, produces partial inhibition of formation of phosphatidic acid in human platelets challenged with thrombin, DC8 or OAG; also induces caspase-mediated apoptosis in glioblastoma cells and in other cancers, but lacks toxicity in noncancerous cells.
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同义词R59949;R 59949
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通路Others
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靶点DGK
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受体DGK
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研究领域——
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适应症——
化学信息
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CAS Number120166-69-0
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分子量489.59
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分子式C28H25F2N3OS
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C1N(CCN2CC/C(CC2)=C(C3=CC=C(F)C=C3)\C4=CC=C(F)C=C4)C(NC5=C1C=CC=C5)=S
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化学全称3-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Dominguez CL, et al. Cancer Discov. 2013 Jul;3(7):782-97.
2. de Chaffoy de Courcelles D, et al. J Biol Chem. 1989 Feb 25;264(6):3274-85.
3. Rodríguez-Liares B, et al. Biochem Pharmacol. 1991 Mar 1;41(5):835-8.
4. Jiang Y, et al. Biochem Pharmacol. 2000 Apr 1;59(7):763-72.
2. de Chaffoy de Courcelles D, et al. J Biol Chem. 1989 Feb 25;264(6):3274-85.
3. Rodríguez-Liares B, et al. Biochem Pharmacol. 1991 Mar 1;41(5):835-8.
4. Jiang Y, et al. Biochem Pharmacol. 2000 Apr 1;59(7):763-72.
产品手册
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R-59949
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