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R-59949

CAS No. 120166-69-0

R-59949 ( R59949;R 59949 )

产品货号. M10724 CAS No. 120166-69-0

A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥437 有现货
5MG ¥680 有现货
10MG ¥1199 有现货
25MG ¥2535 有现货
50MG ¥3969 有现货
100MG ¥5978 有现货
500MG ¥12393 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    R-59949
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets.
  • 产品描述
    A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets; markedly increases PKC activity in platelets stimulated with vasopressin, produces partial inhibition of formation of phosphatidic acid in human platelets challenged with thrombin, DC8 or OAG; also induces caspase-mediated apoptosis in glioblastoma cells and in other cancers, but lacks toxicity in noncancerous cells.
  • 同义词
    R59949;R 59949
  • 通路
    Others
  • 靶点
    DGK
  • 受体
    DGK
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    120166-69-0
  • 分子量
    489.59
  • 分子式
    C28H25F2N3OS
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    O=C1N(CCN2CC/C(CC2)=C(C3=CC=C(F)C=C3)\C4=CC=C(F)C=C4)C(NC5=C1C=CC=C5)=S
  • 化学全称
    3-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Dominguez CL, et al. Cancer Discov. 2013 Jul;3(7):782-97.
2. de Chaffoy de Courcelles D, et al. J Biol Chem. 1989 Feb 25;264(6):3274-85.
3. Rodríguez-Liares B, et al. Biochem Pharmacol. 1991 Mar 1;41(5):835-8.
4. Jiang Y, et al. Biochem Pharmacol. 2000 Apr 1;59(7):763-72.
产品手册
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    A small molecule inhibitor of diacylglycerol kinase (DGK) with IC50 of 0.01-10 uM in isolated platelet membranes and in intact platelets.

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  • CU-3

    CU-3 (DGKα inhibitor CU-3) is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM.