CU-3 ( DGKα inhibitor CU-3 )

产品货号. M12788 CAS No. 1815598-71-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CU-3
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CU-3 (DGKα inhibitor CU-3) is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM.
产品描述

CU-3 (DGKα inhibitor CU-3) is a novel potent, selective diacylglycerol kinase α (DGKα) inhibitor with IC50 of 0.6 uM, targets the catalytic region, but not the regulatory region; CU-3 competitively reduces the affinity of DGKα for ATP, but not diacylglycerol or phosphatidylserine, displays selectivity over other nine isozymes (IC50>7 uM); induces apoptosis in HepG2 hepatocellular carcinoma and HeLa cervical cancer cells while simultaneously enhancing the interleukin-2 production of Jurkat T cells.
同义词

DGKα inhibitor CU-3
通路

Others
靶点

DGK
受体

DGK
研究领域

——
适应症

——

CAS Number

1815598-71-0
分子量

392.46
分子式

C16H12N2O4S3
纯度

>98% (HPLC)
溶解度

——
SMILES

O=S(C1=CC=CC=C1)(NN(C/2=O)C(SC2=C/C=C/C3=CC=CO3)=S)=O
化学全称

5-[(2E)-3-(2-furyl)prop-2-enylidene]-3-[(phenylsulfonyl)amino]2-thioxo-1,3-thiazolidin-4-one

1. Liu K, et al. J Lipid Res. 2016 Mar;57(3):368-79.

计算器

产品手册

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