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Pz-1
CAS No. 1800505-64-9
Pz-1 ( —— )
产品货号. M26403 CAS No. 1800505-64-9
Pz-1 is an inhibitor of VEGFR2 and RET (rearranged during transfection) tyrosine kinase that blocks the blood supply required for RET-stimulated growth.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥389 | 有现货 |
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| 5MG | ￥648 | 有现货 |
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| 10MG | ￥1256 | 有现货 |
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| 25MG | ￥2811 | 有现货 |
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| 50MG | ￥4560 | 有现货 |
|
| 100MG | ￥6577 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Pz-1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Pz-1 is an inhibitor of VEGFR2 and RET (rearranged during transfection) tyrosine kinase that blocks the blood supply required for RET-stimulated growth.
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产品描述Pz-1 is an inhibitor of VEGFR2 and RET (rearranged during transfection) tyrosine kinase that blocks the blood supply required for RET-stimulated growth.(In Vitro):Pz-1(1.0?nM) strongly inhibited phosphorylation of all tested RET oncoproteins in cell-based assays with IC50s of less than 1 nM for both VEGFR2 and RET wild type kinases.(In Vivo):Pz-1 (1.0?mg/kg) abrogated the formation of tumors induced by RET-mutant fibroblasts and blocked the phosphorylation of both RET and VEGFR2 in tumor tissue. Pz-1 featured no detectable toxicity at concentrations of up to 100.0?mg/kg.
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同义词——
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通路Angiogenesis
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靶点VEGFR
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number1800505-64-9
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分子量454.5
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分子式C26H26N6O2
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纯度>98% (HPLC)
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溶解度——
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SMILESCn1cc(cn1)-c1ccc2n(cnc2c1)-c1ccc(CC(=O)Nc2cc(on2)C(C)(C)C)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Morikawa T, Xie H, Wang T, Matsuda H, Yoshikawa M. Bioactive constituents from Chinese natural medicines. XXXII. aminopeptidase N and aldose reductase inhibitors from Sinocrassula indica: structures of sinocrassosides B(4), B(5), C(1), and D(1)-D(3). Chem Pharm Bull (Tokyo). 2008 Oct;56(10):1438-44.
产品手册
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