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Piclamilast
CAS No. 144035-83-6
Piclamilast ( RP 73401; RPR 73401 )
产品货号. M27684 CAS No. 144035-83-6
Piclamilast is a PDE4 inhibitor.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥599 | 有现货 |
|
| 5MG | ￥988 | 有现货 |
|
| 10MG | ￥1596 | 有现货 |
|
| 25MG | ￥3467 | 有现货 |
|
| 50MG | ￥5176 | 有现货 |
|
| 100MG | ￥7209 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Piclamilast
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Piclamilast is a PDE4 inhibitor.
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产品描述Piclamilast is a PDE4 inhibitor.(In Vitro):Piclamilast pre-treatment significantly inhibited the changes in 23 genes via mechanisms involving AP-1 activation and c-Jun phosphorylation at Ser63. The IC50s for Piclamilast was 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively. Piclamilast exhibited IC50 values >100 μM, 40 μM, >100 μM, 14 μM for PDE1, PDE2, PDE3 and PDE5. Respectively.(In Vivo):Initial in vivo studies conducted in severe combined immunodeficiency mice transplanted with NB4 leukemia cells indicate that the enhancing effect of piclamilast on ATRA-induced myeloid maturation translates into a therapeutic benefit.
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同义词RP 73401; RPR 73401
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通路Angiogenesis
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靶点PDE
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number144035-83-6
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分子量381.3
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分子式C18H18Cl2N2O3
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纯度>98% (HPLC)
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溶解度——
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SMILESCOc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Westermann M, et al. Inhibition of human carbonyl reducing enzymes by plant anthrone and anthraquinone derivatives. Chem Biol Interact. 2022 Feb 25;354:109823.
产品手册
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