Phenylbiguanide ( N-Phenylbiguanide | PBG | 1-Phenylbiguanide )

产品货号. M20627 CAS No. 102-02-3

Phenylbiguanide 是一种 5-HT3 受体选择性激动剂（EC50 : 3.0±0.1 μM）。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
100MG	￥316	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

Phenylbiguanide
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Phenylbiguanide 是一种 5-HT3 受体选择性激动剂（EC50 : 3.0±0.1 μM）。
产品描述

Phenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM).
体外实验

Phenylbiguanide (1-Phenylbiguanide) is a 5-HT3 receptor selective agonist with pEC50s of 5.57, 4.07, and 4.47 for r5-HT3A(b), h5-HT3A, m5-HT3A(b) , respectively. The effect of Phenylbiguanide (1-Phenylbiguanide hydrochloride) in promoting the growth of the HT29 cell line is investigated. Phenylbiguanide causes a dose dependent proliferation of HT29 cells after 48 hours incubation. The maximum proliferation is at a 5HT concentration of 12.5 μM (P≤0.01). Phenylbiguanide significantly stimulates the growth of cells at concentrations of 3.125 μM (P≤0.05) and 6.25 μM (P≤0.01).
体内实验

In anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres,is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression.
同义词

N-Phenylbiguanide | PBG | 1-Phenylbiguanide
通路

Endocrinology/Hormones
靶点

5-HT Receptor
受体

5-HT3
研究领域

——
适应症

——

化学信息

CAS Number

102-02-3
分子量

177.21
分子式

C8H11N5
纯度

>98% (HPLC)
溶解度

DMSO:150 mg/mL (846.45 mM)
SMILES

NC(=N)NC(=N)Nc1ccccc1
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.de Vries A Paton JF Lightman SLet al.Characterisation of c-Fos expression in the central nervous system of mice following right atrial injections of the 5-HT3 receptor agonist phenylbiguanide[J].Auton Neurosci. 2005 Dec 30;123(1-2):62-75.

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