Pergolide mesylate salt

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Pergolide mesylate (Pergolide methanesulfonate)，一种 Ergoline 衍生物，是一种有效的，具有口服活性的多巴胺 D1 和 D2 受体 (dopamine D1 和 D2 receptors) 激动剂。Pergolide mesylate 可用于帕金森氏病和高泌乳素血症的研究。

PERGOLIDE MESYLATE is a long-acting dopamine agonist which has been used to treat parkinson disease and hyperprolactinemiabut withdrawn from some markets due to potential for heart valve diseases.(In Vitro):Pergolide (10 nM-50 μM) treatment dose-dependently inhibits H2O2-induced cell death in SH-SY5Y neuroblastoma cells. Pergolide protects SH-SY5Y neuroblastoma cells from cell death specifically induced by H2O2, acting in very low concentrations (nanomolar range) and in very early stages of the neurotoxic intracellular process.(In Vivo):Pergolide (0.3 mg/kg; intraperitoneal injection; daily; 11 days) treatment reduces the number of working/reference memory errors a 6-OHDA-induced rat model of Parkinson's disease. Pergolide facilitates spatial memory and improves brain oxidative balance .

Pergolide (10 nM-50 μM) treatment dose-dependently inhibits H2O2-induced cell death in SH-SY5Y neuroblastoma cells. Pergolide protects SH-SY5Y neuroblastoma cells from cell death specifically induced by H2O2, acting in very low concentrations (nanomolar range) and in very early stages of the neurotoxic intracellular process. TCell Viability Assay Cell Line:SH-SY5Y cells Concentration:0.01 μM, 0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM, 50 μM Incubation Time:Pretreated for 2 hours Result:Dose-dependently inhibited H2O2-induced cell death in SH-SY5Y neuroblastoma cells.

Pergolide (0.3 mg/kg; intraperitoneal injection; daily; 11 days) treatment reduces the number of working/reference memory errors a 6-OHDA-induced rat model of Parkinson's disease. Pergolide facilitates spatial memory and improves brain oxidative balance . Animal Model:Wistar rats (200-250 g) induced with 6-hydroxydopamine (6-OHDA) Dosage:0.3 mg/kg Administration:Intraperitoneal injection; daily; 11 days Result:A reduced number of working/reference memory errors was observed. And significant decreased of MDA level.

LY127809 | NSC 319773

Endocrinology/Hormones

5-HT Receptor

5-HT receptor| Adrenergic receptor| Dopamine receptor

Neurological Disease

——

66104-23-2

410.59

C20H30N2O3S2

>98% (HPLC)

DMSO 10 mg/mL;Water 82 mg/mL

[H][C@@]1(N(CCC)C[C@H](CSC)C[C@@]12[H])CC3=CNC4=C3C2=CC=C4.CS(=O)(O)=O

8-beta-((Methylthio)methyl)-6-propylergoline methanesulfonate

(-20℃)

With Ice Pack

≥ 2 years