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Phenoxodiol
CAS No. 81267-65-4
Phenoxodiol ( Idronoxil; Dehydroequol; Haginin E )
产品货号. M26785 CAS No. 81267-65-4
Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥713 | 有现货 |
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| 5MG | ￥1191 | 有现货 |
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| 10MG | ￥1936 | 有现货 |
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| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Phenoxodiol
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis.
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产品描述Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner. Phenoxodiol also inhibits DNA topoisomerase II.(In Vitro):Phenoxodiol, at concentrations >or=1 microg/ml (4 microM), inhibited proliferation and reduced the viability of healthy donor-derived PBMC. In contrast, lower Phenoxodiol concentrations (0.05-0.5 microg/ml) augmented, upon 3-day incubation, peripheral blood mononuclear cells cytotoxicity. Experiments with purified CD56(+) lymphocytes revealed that Phenoxodiol enhanced the lytic function of natural killer cells by directly stimulating this lymphocytic subpopulation.(In Vivo):Balb/C mice administered low-dose Phenoxodiol exhibited significantly reduced tumour growth rates and prolonged survival (in 40% of the animals) in a colon cancer model.
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同义词Idronoxil; Dehydroequol; Haginin E
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通路Apoptosis
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靶点Apoptosis
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number81267-65-4
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分子量240.3
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分子式C15H12O3
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纯度>98% (HPLC)
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溶解度——
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SMILESOc1ccc(cc1)C1=Cc2ccc(O)cc2OC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Afifi MS, et, al. Cucurbitacins of Cucumis prophetarum and Cucumis prophetarum.J Chem Ecol 25, 847–859 (1999).
产品手册
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