PF-CBP1 ( PF CBP1 )

产品货号. M13078 CAS No. 1962928-21-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

PF-CBP1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, highly selective CBP/p300 bromodomains inhibitor with IC50 of 125 nM and 363 nM, respectively.
产品描述

A potent, highly selective CBP/p300 bromodomains inhibitor with IC50 of 125 nM and 363 nM, respectively; displays >100-fold selectivity for the bromodomain of CBP over those of BRD4 and a panel of other proteins; reduces the expression of inflammatory cytokines by LPS-stimulated primary macrophages, also suppresses the expression of RGS4 in primary cortical neurons.
同义词

PF CBP1
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

CREB
研究领域

——
适应症

——

CAS Number

1962928-21-7
分子量

488.60
分子式

C29H36N4O3
纯度

>98% (HPLC)
溶解度

DMSO: 100 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

CCCOC1=CC=C(C=C1)CCC2=NC3=C(N2CCN4CCOCC4)C=CC(=C3)C5=C(ON=C5C)C
化学全称

4-(2-(5-(3,5-dimethylisoxazol-4-yl)-2-(4-propoxyphenethyl)-1H-benzo[d]imidazol-1-yl)ethyl)morpholine

1. Chekler EL, et al. Chem Biol. 2015 Dec 17;22(12):1588-96.

计算器

产品手册

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