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OP-1074
CAS No. ——
OP-1074 ( OP1074 )
产品货号. M17021 CAS No. ——
OP-1074 (OP1074) is a potent, selective ER degrader (SERD), shows specific antiestrogenic activity for both ERα and Erβ.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称OP-1074
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述OP-1074 (OP1074) is a potent, selective ER degrader (SERD), shows specific antiestrogenic activity for both ERα and Erβ.
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产品描述OP-1074 (OP1074) is a potent, selective ER degrader (SERD), shows specific antiestrogenic activity for both ERα and ERβ, inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC50 of 1.6 and 3.2nM, respectively; displays no activity on other steroid receptors; inhibits E2-induced proliferation of breast cells (MCF-7 cell IC50=7 nM) and degrades ERα, inhibiting ER-mediated signaling with IC50 of 3.2 nM; shrinks tumors in tamoxifen-resistant xenograft model.
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同义词OP1074
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通路Endocrinology/Hormones
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靶点Estrogen Receptor/ERR
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受体Estrogen Receptor/ERR
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量443.54
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分子式C28H29NO4
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称(S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-(((R)-3-methylpyrrolidin-1-yl)methoxy)phenyl)-2H-chromen-7-ol
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Fanning SW, et al. Nat Commun. 2018 Jun 18;9(1):2368.
产品手册
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