OF-1 ( SGC OF-1; SGC OF 1; SGC OF1; SGCOF1; SGC-OF-1; OF-1 )

产品货号. M16600 CAS No. 919973-83-4

OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM.

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥405	有现货
5MG	￥583	有现货
10MG	￥1069	有现货
25MG	￥2211	有现货
50MG	￥4261	有现货
100MG	￥5921	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

拼团产品询价大包装询价加入购物车

生物学信息

产品名称

OF-1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM.
产品描述

OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM; displays good selectivity against other bromodomains, 39-fold selectivity over closest off-target BRD4.
同义词

SGC OF-1; SGC OF 1; SGC OF1; SGCOF1; SGC-OF-1; OF-1
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

BRPF1B;BRPF2
研究领域

Other Indications
适应症

——

化学信息

CAS Number

919973-83-4
分子量

440.31
分子式

C17H18BrN3O4S
纯度

>98% (HPLC)
溶解度

DMSO: 8.8 mg/mL (20 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=S(C1=CC=C(Br)C=C1C)(NC2=C(OC)C=C(N3C)C(N(C)C3=O)=C2)=O
化学全称

4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Demont EH, et al. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5.
2. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.
3.Meier JC, et al. ACS Chem Biol. 2017 Oct 20;12(10):2619-2630.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册

关联产品

BET inhibitor CF53

BET inhibitor CF53 is a highly potent, orally active inhibitor of bromodomain and extra-terminal (BET) with Ki of <1 nM (BRD4 BD1).
GNE-375

GNE-375 is a potent, selective BRD9 inhibitor with IC50 of 5 nM.
GNE-207

GNE-207 (GNE207) is a novel potent, selective, orally active CBP/p300 bromodomain with IC50 of 1.0 nM.

Product			Quantity Required*
Name *			E-mail Address *
Organization *			Phone Number
Remarks