OF-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

OF-1 是一种有效的溴结构域抑制剂，可抑制 BRPF1B/2/3 溴结构域，Kd 为 0.1/0.5/2.4 uM。

OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM; displays good selectivity against other bromodomains, 39-fold selectivity over closest off-target BRD4.

OF-1 (1 μM and 2 μM, 0, 1, 2, and 3 days) causes significant reductions in the number of multinucleated tartrate-resistant acid phosphatase (TRAP) positive cells.OF-1 is the only inhibitor to completely suppress the fusion into multinucleated “osteoclast-like” cells. Cell Viability Assay Cell Line:Murine BMCs during differentiation with 10 ng/mL RANKL.Concentration:1 μM and 2 μM.Incubation Time:0, 1, 2, and 3 days.Result:Particularly strong at day 2 after RANKL-induced differentiation.

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SGC OF-1 | SGC OF 1 | SGC OF1 | SGCOF1 | SGC-OF-1 | OF-1

Chromatin/Epigenetic

Bromodomain

BRPF1B|BRPF2

Other Indications

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919973-83-4

440.312

C17H18BrN3O4S

>98% (HPLC)

DMSO: 8.8 mg/mL (20 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )

O=S(C1=CC=C(Br)C=C1C)(NC2=C(OC)C=C(N3C)C(N(C)C3=O)=C2)=O

4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide

(-20℃)

With Ice Pack

≥ 2 years