JQ1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively.

(+)-JQ-1 (JQ1) is a potent, selective, cell-permeable BET bromodomain inhibitor with IC50 of 77 nM/33 nM for BRD4 BD1 and BD2, respectively; induces rapid expression of keratin in treated NMC 797 cells, displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models.

JQ-1;(+)-JQ-1

Chromatin/Epigenetic

Bromodomain

BRD4(1);BRD4(2)

Cancer

——

1268524-70-4

456.99

C23H25ClN4O2S

>98% (HPLC)

DMSO: ≥ 45 mg/mL

O=C(OC(C)(C)C)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1

6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-

(-20℃)

With Ice Pack

≥ 2 years