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Nintedanib
CAS No. 656247-17-5
Nintedanib ( BIBF-1120;BIBF1120 )
产品货号. M15494 CAS No. 656247-17-5
A potent triple angiokinase (VEGFR/PDGFR/FGFR) inhibitor with IC50 of 5/38/18/104/5 nM for VEGFR-2/FGFR-1/PDGFRα/VEGFR-1/VEGFR-3, respectively.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥308 | 有现货 |
|
| 10MG | ￥437 | 有现货 |
|
| 50MG | ￥518 | 有现货 |
|
| 100MG | ￥753 | 有现货 |
|
| 200MG | ￥1166 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Nintedanib
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent triple angiokinase (VEGFR/PDGFR/FGFR) inhibitor with IC50 of 5/38/18/104/5 nM for VEGFR-2/FGFR-1/PDGFRα/VEGFR-1/VEGFR-3, respectively.
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产品描述A potent triple angiokinase (VEGFR/PDGFR/FGFR) inhibitor with IC50 of 5/38/18/104/5 nM for VEGFR-2/FGFR-1/PDGFRα/VEGFR-1/VEGFR-3, respectively; inhibits MAPK and Akt signaling pathways, show inhibition of cell proliferation (EC50=10-80 nM); is fully efficacious in xenograft models and orally active.Lung Cancer Approved
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同义词BIBF-1120;BIBF1120
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通路Angiogenesis
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靶点VEGFR
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受体FLT3;Lck;VEGFR1;VEGFR2;VEGFR3;FGFR1;FGFR2;PDGFRα
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研究领域Cancer
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适应症Lung Cancer
化学信息
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CAS Number656247-17-5
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分子量539.62
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分子式C31H33N5O4
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESCN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N/C(=C\3/C4=C(C=C(C=C4)C(=O)OC)NC3=O)/C5=CC=CC=C5
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化学全称(Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Roth GJ, et al. J Med Chem. 2009 Jul 23;52(14):4466-80.
2. Hilberg F, et al. Cancer Res. 2008 Jun 15;68(12):4774-82.
3. Kudo K, et al. Clin Cancer Res. 2011 Mar 15;17(6):1373-81.
2. Hilberg F, et al. Cancer Res. 2008 Jun 15;68(12):4774-82.
3. Kudo K, et al. Clin Cancer Res. 2011 Mar 15;17(6):1373-81.
产品手册
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