021-51111890
购物车（）
sales@molnova.cn
Naronapride
CAS No. 860174-12-5
Naronapride ( ATI-7505 )
产品货号. M16233 CAS No. 860174-12-5
Naronapride (ATI-7505) is a potent, selective and orally active 5-HT4 receptor agonist with Ki of 1.4 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥6140 | 有现货 |
|
| 50MG | ￥22559 | 有现货 |
|
| 100MG | ￥28512 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Naronapride
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Naronapride (ATI-7505) is a potent, selective and orally active 5-HT4 receptor agonist with Ki of 1.4 nM.
-
产品描述Naronapride (ATI-7505) is a potent, selective and orally active 5-HT4 receptor agonist with Ki of 1.4 nM; displays negligible affinity for Kv11.1 channels (Ki=24,500 nM), and no effect on cardiac repolarization; shows potential for treatment of gastrointestinal motility disorders.Other Indication Phase 2 Clinical
-
同义词ATI-7505
-
通路Endocrinology/Hormones
-
靶点5-HT Receptor
-
受体5-HT Receptor
-
研究领域Other Indications
-
适应症Other Disease
化学信息
-
CAS Number860174-12-5
-
分子量537.10
-
分子式C27H41ClN4O5
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESO=C(O[C@H]1CN2CCC1CC2)CCCCCN3C[C@H](OC)[C@H](NC(C4=CC(Cl)=C(N)C=C4OC)=O)CC3
-
化学全称[(3R)-1-azabicyclo[2.2.2]octan-3-yl] 6-[(3S,4R)-4-[(4-amino-5-chloro-2-methoxybenzoyl)amino]-3-methoxypiperidin-1-yl]hexanoate
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Manabe N, et al. Expert Opin Investig Drugs. 2010 Jun;19(6):765-75.
2. Bowersox SS, et al. Drug Metab Dispos. 2011 Jul;39(7):1170-80.
3. Hoffman JM, et al. Gastroenterology. 2012 Apr;142(4):844-854.e4.
4. Camilleri M, et al. Neurogastroenterol Motil. 2007 Jan;19(1):30-8.
2. Bowersox SS, et al. Drug Metab Dispos. 2011 Jul;39(7):1170-80.
3. Hoffman JM, et al. Gastroenterology. 2012 Apr;142(4):844-854.e4.
4. Camilleri M, et al. Neurogastroenterol Motil. 2007 Jan;19(1):30-8.
产品手册
关联产品
-
Vortioxetine
Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.
-
Tropisetron
Tropisetron is an α7-nicotinic receptor agonist and 5-HT3 receptor antagonist with Kis of 6.9 nM and 5.3 nM, respectively.
-
5-Methoxytryptamine
5-Methoxytryptamine is a tryptamine derivative that acts as a full agonist at the 5-HT1 5-HT2 5-HT4 5-HT6 and 5-HT7 receptors.
