NIBR-3049 ( TCS-21311 )

产品货号. M11072 CAS No. 1260181-14-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

NIBR-3049
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NIBR-3049 (TCS-21311) 是一种有效的、高选择性的 JAK3 抑制剂，IC50 为 8 nM。
产品描述

NIBR-3049 (TCS-21311) is a potent, highly selective JAK3 inhibitor with IC50 of 8 nM, displays >100-fold selectivity over JAK1, JAK2 and TYK2, also inhibits PKCα, PKCθ, and GSK3β with IC50 of 13, 68, and 3 nM, respectively.
体外实验

TCS 21311 (NIBR3049) exhibits IC50 values of 1.017, 2.550 and 8.055 μM for JAK1, JAK2 and TYK2, respectively?in a enzymatic Jak assay.TCS 21311 (NIBR3049) shows moderate activity in this cellular assay (IC50=689 nM, Jurkat cells), which is in good agreement with its enzymatic Pkc activity.
体内实验

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同义词

TCS-21311
通路

Angiogenesis
靶点

JAK
受体

JAK
研究领域

——
适应症

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CAS Number

1260181-14-3
分子量

526.51
分子式

C27H25F3N4O4
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 100 mg/mL (189.93 mM)
SMILES

O=C(C(C1=CC(N2CCN(C(C(C)(O)C)=O)CC2)=CC=C1C(F)(F)F)=C3C4=CNC5=C4C=CC=C5)NC3=O
化学全称

3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

1. Thoma G, et al. J Med Chem. 2011 Jan 13;54(1):284-8.

计算器

产品手册

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