NI-57 ( BRPF inhibitor NI57 )

产品货号. M12933 CAS No. 1883548-89-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

NI-57
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NI-57 is a potent inhibitor of the bromodomain of the BRPFs and binds to BRPF1B, BRPF2 and BRPF3 and with KD of 31 nM,108 nM and 408 nM (ITC), respectively.
产品描述

NI-57 is a potent inhibitor of the bromodomain of the BRPFs and binds to BRPF1B, BRPF2 and BRPF3 and with KD of 31 nM,108 nM and 408 nM (ITC), respectively; shows highly selectivity against other non-Class IV bromodomains, including the BETs, as measured by both biophysical and biochemical methods; displays 32-fold selectivity over the closest off-target BRD9; shows accelerated FRAP recovery at 1 uM in the BRPF2 FRAP assay preventing binding of full-length BRPF2 to chromatin.
同义词

BRPF inhibitor NI57
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

Cancer
适应症

——

CAS Number

1883548-89-7
分子量

383.42
分子式

C19H17N3O4S
纯度

>98% (HPLC)
溶解度

DMSO : ≥ 83.3 mg/mL 217.26 mM
SMILES

O=S(C1=CC=C(C#N)C=C1OC)(NC2=CC3=C(N(C)C(C(C)=C3)=O)C=C2)=O
化学全称

4-cyano-N-(1,2-dihydro-1,3-dimethyl-2-oxo-6-quinolinyl)-2-methoxy-benzenesulfonamide

1. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.
2. Igoe N, et al. J Med Chem. 2017 Aug 10. doi: 10.1021/acs.jmedchem.7b00611.

计算器

产品手册

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