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NCT-502

CAS No. 1542213-00-2

NCT-502 ( N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide )

产品货号. M26771 CAS No. 1542213-00-2

NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥267 有现货
5MG ¥421 有现货
10MG ¥640 有现货
25MG ¥1312 有现货
50MG ¥2049 有现货
100MG ¥3540 有现货
500MG ¥7954 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    NCT-502
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells.
  • 产品描述
    NCT-502 is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-derived serine production and it has an IC50 of 3.7 μM against PHGDH.(In Vitro):NCT-502 is cytotoxic to MDA-MB-468 (EC50: 15.2 μM).
  • 同义词
    N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide
  • 通路
    Metabolic Enzyme/Protease
  • 靶点
    Dehydrogenase
  • 受体
    Crimean-Congo hemorrhagic fever virus (CCHFV); Nucleoside Antimetabolite/Analog
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1542213-00-2
  • 分子量
    395.5
  • 分子式
    C18H20F3N5S
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    Cc1cc(C)nc(NC(=S)N2CCN(CC2)c2ccc(cn2)C(F)(F)F)c1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.
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