Manitimus

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Manitimus 是一种 dehydroorotate dehydrogenase 的抑制剂，同时为有效的免疫抑制药。Manitimus 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

Manitimus is an inhibitor of dehydroorotate dehydrogenase, and a potent immunosuppressive agent. Manitimus is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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In the Manitimus-treated rats, there is a dose-related, differential effect: mean survival is 15.7 days in group 4 (Manitimus 5 mg/kg), 19.1 days in group 5 (Manitimus 10 mg/kg) and 25.4 days in group 6 (Manitimus 20 mg/kg). Manitimus (15 mg/kg, p.o.) results in a significant decrease in neointimal area and percentage of stenosis versus the control rats, and diminishes the effect that CMV infection results in a significant increase in intimal and medial cross-sectional area and medial wall thickness of the vein grafts.

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Metabolic Enzyme/Protease

Dehydrogenase

Dehydrogenase

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202057-76-9

308.26

C15H11F3N2O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (811.00 mM; 超声助溶 )

C(\C(NC1=CC=C(C(F)(F)F)C=C1)=O)(=C(/CCC#C)\O)/C#N

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(-20℃)

With Ice Pack

≥ 2 years