NCH-51

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NCH-51 is the S-isobutyryl prodrug of NCH-31, which is a potent HDAC inhibitor with IC50 of 48 nM for HDAC1.

NCH-51 is the S-isobutyryl prodrug of NCH-31, which is a potent HDAC inhibitor with IC50 of 48 nM for HDAC1, inhibits cell proliferation of NCI-H460 and MDA-MB-231 with IC50 of 2.1 and 4.4 uM; inhibits the cell growth of a variety of lymphoid malignant cells through apoptosis induction, more effectively than SAHA, upregulates p21 and downregulated anti-apoptotic molecules including survivin, bcl-w and c-FLIP; also induces expression of latent HIV-1 through the Sp1 sites with minimal cytotoxicit in latently infected-cells.

NCH51

Cell Cycle/DNA Damage

HDAC

HDAC

Cancer

——

848354-66-5

390.56

C20H26N2O2S2

>98% (HPLC)

10 mM in DMSO

CC(C)C(SCCCCCCC(NC1=NC(C2=CC=CC=C2)=CS1)=O)=O

Propanethioic acid, 2-methyl-, S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester

(-20℃)

With Ice Pack

≥ 2 years