CM-675 ( CM675;CM 675 )

产品货号. M12901 CAS No. 1872466-47-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CM-675
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CM-675 (CM675) is a potent, dual PDE5 and classI-HDAC inhibitor with IC50 of 114/673 nM for PDE5A/HDAC1, respectively.
产品描述

CM-675 (CM675) is a potent, dual PDE5 and classI-HDAC inhibitor with IC50 of 114/673 nM for PDE5A/HDAC1, respectively; displays >10-fold selectivity over HDAC6; induces significant cellular responses (AcH3K9 and pCREB) at low concentrations (26-100 nM) with little cytotoxicity; shows an adequate ADME-Tox profile and in vivo target engagement (histone acetylation and cAMP/cGMP response element-binding (CREB) phosphorylation) in the central nervous system (CNS).
同义词

CM675;CM 675
通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

HDAC
研究领域

——
适应症

——

CAS Number

1872466-47-1
分子量

536.64
分子式

C31H32N6O3
纯度

>98% (HPLC)
溶解度

——
SMILES

CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)CC4=CC=C(C=C4)C(=O)NC5=CC=CC=C5N)OCC)C
化学全称

N-(2-aminophenyl)-4-[[4-ethoxy-3-(1-methyl-7-oxo-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-5-yl)phenyl]methyl]benzamide

1. Rabal O, et al. ACS Chem Neurosci. 2018 Dec 10. doi: 10.1021/acschemneuro.8b00648.

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产品手册

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