021-51111890
购物车（）
sales@molnova.cn
AES-350
CAS No. 847249-57-4
AES-350 ( —— )
产品货号. M24840 CAS No. 847249-57-4
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2576 | 有现货 |
|
| 10MG | ￥4277 | 有现货 |
|
| 25MG | ￥7071 | 有现货 |
|
| 50MG | ￥9558 | 有现货 |
|
| 100MG | ￥13122 | 有现货 |
|
| 500MG | ￥26163 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称AES-350
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively).
-
产品描述AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, and >1μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.
-
同义词——
-
通路Cell Cycle/DNA Damage
-
靶点HDAC
-
受体HDAC11;HDAC3;HDAC6
-
研究领域——
-
适应症——
化学信息
-
CAS Number847249-57-4
-
分子量312.4
-
分子式C18H20N2O3
-
纯度>98% (HPLC)
-
溶解度DMSO:100 mg/mL (320.14 mM; Need ultrasonic)
-
SMILESCC(C)(C)C1=CC=C(C(NC2=CC=C(C(NO)=O)C=C2)=O)C=C1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Andrew E Shouksmith, et al. Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.
产品手册
关联产品
-
NCC-149
A potent and selective HDAC8 inhibitor with IC50 of 70 nM.
-
HDACi-4b
A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells.
-
Tubastatin A
Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays.
