AES-350 ( —— )

产品货号. M24840 CAS No. 847249-57-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AES-350
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively).
产品描述

AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, and >1μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.
同义词

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通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

HDAC11;HDAC3;HDAC6
研究领域

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适应症

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1.Andrew E Shouksmith, et al. Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.

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产品手册

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