021-51111890
购物车（）
sales@molnova.cn
HDACi-4b
CAS No. 537034-15-4
HDACi-4b ( NKL22;NKL-22 )
产品货号. M14906 CAS No. 537034-15-4
A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥243 | 有现货 |
|
| 10MG | ￥381 | 有现货 |
|
| 25MG | ￥786 | 有现货 |
|
| 50MG | ￥1482 | 有现货 |
|
| 100MG | ￥2859 | 有现货 |
|
| 500MG | ￥6764 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称HDACi-4b
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells.
-
产品描述A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells; reverses FXN silencing in primary lymphocytes from individuals with Friedreich's ataxia; directly affects the histones associated with FXN, increasing acetylation at particular lysine residues on histones H3 and H4 (H3K14, H4K5 and H4K12); significantly improves motor performance, overall appearance, and body weight in an HD mouse model.
-
同义词NKL22;NKL-22
-
通路Cell Cycle/DNA Damage
-
靶点HDAC
-
受体HDAC
-
研究领域Other Indications
-
适应症——
化学信息
-
CAS Number537034-15-4
-
分子量325.40
-
分子式C19H23N3O2
-
纯度>98% (HPLC)
-
溶解度DMSO: ≥ 29 mg/mL
-
SMILESO=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O
-
化学全称Heptanediamide, N1-(2-aminophenyl)-N7-phenyl-
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Jia H, et al. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E56-64.
2. Thomas EA, et al. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9.
3. Herman D, et al. Nat Chem Biol. 2006 Oct;2(10):551-8.
2. Thomas EA, et al. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9.
3. Herman D, et al. Nat Chem Biol. 2006 Oct;2(10):551-8.
产品手册
关联产品
-
Vorinostat
A potent HDAC inhibitor, inhibits the activities of HDAC1 and HDAC3 with IC50 of 10 nM and 20 nM, respectively.
-
Pyroxamide
Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM).
-
Valproic acid
A HDAC inhibitor that selectively inhibits the catalytic activity of class I HDACs, and induces proteasomal degradation of HDAC2.
