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HDACi-4b
CAS No. 537034-15-4
HDACi-4b ( NKL22;NKL-22 )
产品货号. M14906 CAS No. 537034-15-4
A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥243 | 有现货 |
|
| 10MG | ￥381 | 有现货 |
|
| 25MG | ￥786 | 有现货 |
|
| 50MG | ￥1482 | 有现货 |
|
| 100MG | ￥2859 | 有现货 |
|
| 500MG | ￥6764 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称HDACi-4b
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells.
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产品描述A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells; reverses FXN silencing in primary lymphocytes from individuals with Friedreich's ataxia; directly affects the histones associated with FXN, increasing acetylation at particular lysine residues on histones H3 and H4 (H3K14, H4K5 and H4K12); significantly improves motor performance, overall appearance, and body weight in an HD mouse model.
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同义词NKL22;NKL-22
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC
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研究领域Other Indications
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适应症——
化学信息
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CAS Number537034-15-4
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分子量325.40
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分子式C19H23N3O2
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 29 mg/mL
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SMILESO=C(NC1=CC=CC=C1N)CCCCCC(NC2=CC=CC=C2)=O
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化学全称Heptanediamide, N1-(2-aminophenyl)-N7-phenyl-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Jia H, et al. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E56-64.
2. Thomas EA, et al. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9.
3. Herman D, et al. Nat Chem Biol. 2006 Oct;2(10):551-8.
2. Thomas EA, et al. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15564-9.
3. Herman D, et al. Nat Chem Biol. 2006 Oct;2(10):551-8.
产品手册
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