Mepazine ( Pecazine )

产品货号. M26752 CAS No. 60-89-9

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产品名称

Mepazine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Mepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM.
产品描述

Mepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability.(In Vitro):Mepazine (5, 10, and 20 μM) decreases cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.(In Vivo):In female NSG mice with a murine DLBCL xenogeneic tumor model, Mepazine (16 mg/kg; i.p.) interferes with the growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10. Mepazine strongly impairs the expansion of OCI-Ly10 with daily administration.
同义词

Pecazine
通路

Apoptosis
靶点

Apoptosis
受体

Androgen Receptor
研究领域

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适应症

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1.Toure BAKARY-BARRY, et al. Indole compounds as androgen receptor modulators.WO2022020342

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