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Mepazine
CAS No. 60-89-9
Mepazine ( Pecazine )
产品货号. M26752 CAS No. 60-89-9
Mepazine 是一种有效的选择性 MALT1 抑制剂。 Mepazine 抑制 GSTMALT1 全长和 GSTMALT1 325-760，IC50 分别为 0.83 μM 和 0.42 μM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥316 | 有现货 |
|
| 10MG | ￥454 | 有现货 |
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| 25MG | ￥753 | 有现货 |
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| 50MG | ￥1158 | 有现货 |
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| 100MG | ￥1604 | 有现货 |
|
| 200MG | ￥2527 | 有现货 |
|
| 500MG | ￥4261 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Mepazine
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Mepazine 是一种有效的选择性 MALT1 抑制剂。 Mepazine 抑制 GSTMALT1 全长和 GSTMALT1 325-760，IC50 分别为 0.83 μM 和 0.42 μM。
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产品描述Mepazine is a potent and selective inhibitor of MALT1. Mepazine inhibits GSTMALT1 full length and GSTMALT1 325-760 with IC50s of 0.83 μM and 0.42 μM. Mepazine enhances apoptosis and affects the cell viability.(In Vitro):Mepazine (5, 10, and 20 μM) decreases cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.(In Vivo):In female NSG mice with a murine DLBCL xenogeneic tumor model, Mepazine (16 mg/kg; i.p.) interferes with the growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10. Mepazine strongly impairs the expansion of OCI-Ly10 with daily administration.
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体外实验Mepazine (5-20 μM; 4 days) causes a decrease of cell viability in the activated B cell subtype of diffuse large B cell lymphoma (ABCDLBCL) cells, without significantly affecting GCB-DLBCL cells. Cell Viability Assay Cell Line:ABC-DLBCL cell lines (HBL1, OCI-Ly3, U2932, TMD8, OCI-Ly10) and GCB-DLBCL cell lines (BJAB, Su-DHL-6, Su-DHL-4)Concentration:5, 10, and 20 μM Incubation Time:4 days Result:Caused a decrease of cell viability in the ABC-DLBCL cells HBL1, OCI-Ly3, U2932, and TMD8, without significantly affecting GCB-DLBCL cells.
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体内实验Mepazine (16 mg/kg; intraperitoneal administration) interferes with growth and induces apoptosis of ABC-DLBCL cell line OCI-Ly10 in NOD/scid IL-2Rgnull (NSG) mice with a murine DLBCL xenogeneic tumor model. Daily administration of Mepazine strongly impairs the expansion of the ABC-DLBCL cell line OCI-Ly10. Animal Model:6- to 8-week-old female NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice with a murine DLBCL xenogeneic tumor modelDosage:400 μg per animal (25 g), corresponding to approximately 16 mg/kg. Administration:Intraperitoneal administration; started 1 or 12 days after transplantation and given continuously every 24 hr; daily application Result:Daily administration strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10.
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同义词Pecazine
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通路Apoptosis
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靶点Apoptosis
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受体Androgen Receptor
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研究领域——
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适应症——
化学信息
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CAS Number60-89-9
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分子量310.46
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分子式C19H22N2S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (322.10 mM)
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SMILESCN1CCCC(CN2c3ccccc3Sc3ccccc23)C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Toure BAKARY-BARRY, et al. Indole compounds as androgen receptor modulators.WO2022020342
产品手册
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