MS-402 ( MS402;MS 402 )

产品货号. M12552 CAS No. 1672684-68-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

MS-402
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

MS-402 (MS402) is a potent, selective inhibitor of the first bromodomain of BET (BRD4-BD1) with Ki of 77 nM.
产品描述

MS-402 (MS402) is a potent, selective inhibitor of the first bromodomain of BET (BRD4-BD1) with Ki of 77 nM; shows about 10-fold weaker affinity for BRD4-BD2 (Ki=718 nM) and CBP, and >50-fold for PCAF, SMARCA4, BPTF and BAZ2B; selectively blocks Th17 cell differentiation with a little or almost no effect on Th1 or Th2 and Treg cells; preferentially renders Brd4 binding to Th17 signature gene loci over those of housekeeping genes and reduces Brd4 recruitment of p-TEFb to phosphorylate and activate RNA polymerase II for transcription elongation; prevents and ameliorates T-cell transfer-induced colitis in mice.
同义词

MS402;MS 402
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

1672684-68-2
分子量

370.83
分子式

C20H19ClN2O3
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(NC1=CC=C(OC)C=C1)C2=CC=C(NC3=C(C)C(CC3)=O)C(Cl)=C2
化学全称

3-chloro-N-(4-methoxyphenyl)-4-((2-methyl-3-oxocyclopent-1-en-1-yl)amino)benzamide

1. Cheung K, et al. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2952-2957.

计算器

产品手册

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