RX-37 ( RX 37;RX37;BET bromodomain inhibitor RX-37 )

产品货号. M12417 CAS No. 1627715-60-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

RX-37
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM.
产品描述

A potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM for BD1 and BD2 domains of BRD2, BRD3, and BRD4; shows an excellent selectivity over other non-BET bromodomain-containing proteins with the exception of CREBBP (Kd=670 nM); potently and selectively inhibits cell growth in human acute leukemia cell lines harboring the rearranged MLL1 gene (IC50=20 nM for MV4;11 cells).
同义词

RX 37;RX37;BET bromodomain inhibitor RX-37
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

1627715-60-9
分子量

413.48
分子式

C24H23N5O2
纯度

>98% (HPLC)
溶解度

——
SMILES

COC1=C(C2=C(C)ON=C2C)C=C(NC3=C4C(C5=C(C)NN=C5C6CC6)=NC=C3)C4=C1
化学全称

4-(1-(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-8-methoxy-5H-pyrido[4,3-b]indol-7-yl)-3,5-dimethylisoxazole

1. Ran X, et al. J Med Chem. 2015 Jun 25;58(12):4927-39.

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产品手册

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