CPI644 ( CPI 644;CPI-644 )

产品货号. M12986 CAS No. 1904647-34-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

CPI644
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CPI644is a potent, selective, cell-active CBP/EP300 bromodomain inhibitor.
产品描述

CPI644is a potent, selective, cell-active CBP/EP300 bromodomain inhibitor with IC50 of 0.18 uM for CBP; displays little to no (>400-fold selectivity) activity for BRD9, BRD4, BRPF1, TRIM24, BRG1 and BACF (IC50>10 uM); inhibits CBP bromodomain binding in a dose-dependent manner with cellular EC50 of 0.53 uM, reduces FOXP3 expression both at protein and transcript levels with no appreciable effect on cell viability.
同义词

CPI 644;CPI-644
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

1904647-34-2
分子量

357.43
分子式

C18H19N3O3S
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C1NC2=CC=CC(C3=NC(C)=CN3C)=C2N[C@H](C)C1
化学全称

(R,E)-2-(2-(4-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-6-yl)vinyl)benzenesulfonamide

1. Ghosh S, et al. J Biol Chem. 2016 Jun 17;291(25):13014-27.

计算器

产品手册

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CPI644is a potent, selective, cell-active CBP/EP300 bromodomain inhibitor.
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