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MRT67307
CAS No. 1190378-57-4
MRT67307 ( MRT 67307;MRT-67307 )
产品货号. M10651 CAS No. 1190378-57-4
MRT67307 is a potent, dual inhibitor of IKKε and TBK-1 with IC50 of 160 and 19 nM at 0.1 mM ATP in vitro, also potently inhibit ULK1 and ULK2 in vitro (IC50=45 and 38 nM) and block autophagy in cells.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥624 | 有现货 |
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| 10MG | ￥1029 | 有现货 |
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| 25MG | ￥2041 | 有现货 |
|
| 50MG | ￥3937 | 有现货 |
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| 100MG | ￥5605 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称MRT67307
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述MRT67307 is a potent, dual inhibitor of IKKε and TBK-1 with IC50 of 160 and 19 nM at 0.1 mM ATP in vitro, also potently inhibit ULK1 and ULK2 in vitro (IC50=45 and 38 nM) and block autophagy in cells.
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产品描述MRT67307 is a potent, dual inhibitor of IKKε and TBK-1 with IC50 of 160 and 19 nM at 0.1 mM ATP in vitro, also potently inhibit ULK1 and ULK2 in vitro (IC50=45 and 38 nM) and block autophagy in cells; the autophagy-inhibiting capacity of MRT67307 is specifically through ULK1, results in accumulation of stalled early autophagosomal structures in treated cells; increases IL-10 production and suppresses proinflammatory cytokine production in macrophages, increases CREB-dependent gene transcription by promoting the dephosphorylation of CRTC3; also inhibits MARK, NUAK and SIK isoforms in vitro with comparable potency to the IKK-related kinases.
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同义词MRT 67307;MRT-67307
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通路Autophagy
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靶点ULK
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受体IKK;TBK1
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研究领域Inflammation/Immunology
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适应症——
化学信息
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CAS Number1190378-57-4
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分子量464.60
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分子式C26H36N6O2
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESC1CC(C1)C(=O)NCCCNC2=NC(=NC=C2C3CC3)NC4=CC=CC(=C4)CN5CCOCC5
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化学全称Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Clark K, et al. Biochem J. 2011 Feb 15;434(1):93-104.
2. Clark K, et al. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91.
3. Petherick KJ, et al. J Biol Chem. 2015 May 1;290(18):11376-83.
2. Clark K, et al. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91.
3. Petherick KJ, et al. J Biol Chem. 2015 May 1;290(18):11376-83.
产品手册
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MRT67307
MRT67307 is a potent, dual inhibitor of IKKε and TBK-1 with IC50 of 160 and 19 nM at 0.1 mM ATP in vitro, also potently inhibit ULK1 and ULK2 in vitro (IC50=45 and 38 nM) and block autophagy in cells.
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