MRT-68921 ( MRT68921;MRT 68921 )

产品货号. M10652 CAS No. 1190379-70-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

MRT-68921
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively.
产品描述

A potent, relatively specific inhibitor of both ULK1 and ULK2 with IC50 of 2.9 and 1.1 nM, respectively; inhibits a number of kinases by over 80% in a broad panel of 80 protein kinases, including TBK1 and AMPK; reduces phospho-ATG13 and blocks autophagy in cells.
同义词

MRT68921;MRT 68921
通路

Autophagy
靶点

ULK
受体

ULK1;ULK2
研究领域

——
适应症

——

CAS Number

1190379-70-4
分子量

434.58
分子式

C25H34N6O
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

CN1CCC2=C(C1)C=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4CCC4)C5CC5
化学全称

Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-

1. Petherick KJ, et al. J Biol Chem. 2015 May 1;290(18):11376-83.

计算器

产品手册

关联产品

SR-20295

SR-20295 (SR20295) is a novel potent ULK1 inhibitor with IC50 of 45 nM.
ULK-101

ULK-101 (ULK101) is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM, inhibits ULK2 with IC50 of 30 nM.
ULK1-IN-1

ULK1-IN-1 highly potent ULK1 inhibitor with IC50 of 8 nM, with no enough selectivity but sufficient potency, a cellular probe of autophagy.