ML364 ( ML 364;ML-364 )

产品货号. M13111 CAS No. 1991986-30-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

ML364
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, selective, reversible deubiquitinase USP2 inhibitor with IC50 of 1.1 uM in biochemical assay.
产品描述

A potent, selective, reversible deubiquitinase USP2 inhibitor with IC50 of 1.1 uM in biochemical assay; also inhibits USP8 (IC50=0.95 uM), shows no against caspase 6/7, MMP1, MMP9 and USP15 and a panel of 102 kinase; increases cellular cyclin D1 degradation and causes cell cycle arrest and shows antiproliferative in cancer cell lines; also decreases homologous recombination-mediated DNA repair.
同义词

ML 364;ML-364
通路

Proteasome/Ubiquitin
靶点

DUB
受体

USP2
研究领域

Cancer
适应症

——

CAS Number

1991986-30-1
分子量

517.54
分子式

C24H18F3N3O3S2
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 33 mg/mL
SMILES

O=C(NC1=NC(C2=CC=CC=C2)=CS1)C3=CC=C(C(F)(F)F)C=C3NS(=O)(C4=CC=C(C)C=C4)=O
化学全称

Benzamide, 2-[[(4-methylphenyl)sulfonyl]amino]-N-(4-phenyl-2-thiazolyl)-4-(trifluoromethyl)-

1. Davis MI, et al. J Biol Chem. 2016 Nov 18;291(47):24628-24640.

计算器

产品手册

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