EOAI3402143 ( Deubiquitinase inhibitor G9;EOAI 3402143 )

产品货号. M12594 CAS No. 1699750-95-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

EOAI3402143
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor.
产品描述

EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor with increased aqueous solubility and greater cellular Usp9x inhibitory activity than WP1130; displays nM apoptotic activity against other myeloma cell lines and diffuse large B-cell lymphomas cells; increases tumor cell apoptosis, and fully blocks or regresses myeloma tumors in mice; also inhibis Usp5.
同义词

Deubiquitinase inhibitor G9;EOAI 3402143
通路

Proteasome/Ubiquitin
靶点

DUB
受体

DUB
研究领域

——
适应症

——

CAS Number

1699750-95-2
分子量

503.42
分子式

C25H28Cl2N4O3
纯度

>98% (HPLC)
溶解度

DMSO : 50 mg/mL 99.32 mM; H2O : < 0.1 mg/mL
SMILES

CCCC(C1=CC=C(C=C1)OCCN2CCOCC2)NC(=O)C(=CC3=C(C=CC(=N3)Cl)Cl)C#N
化学全称

(E)-2-cyano-3-(3,6-dichloropyridin-2-yl)-N-(1-(4-(2-morpholinoethoxy)phenyl)butyl)acrylamide

1. Peterson LF, et al. Blood. 2015 Jun 4;125(23):3588-97.
2. Potu H, et al. Oncotarget. 2014 Jul 30;5(14):5559-69.

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