IU1-47

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IU1-47 是一种有效的、选择性的 USP14 小分子抑制剂，IC50 为 0.6 uM。

IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14; accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome; stimulates autophagic flux in primary neurons.

Western Blot Analysis Cell Line:Murine cortical primary neurons (DIV5) isolated from APPSwe/P301L transgenic animals Concentration:3 μM, 10 and 30 μM Incubation Time:48 hours Result:Significantly decreased Tau and phosphotau species Ser-202/Thr-205 levels. No change in USP14 protein level.

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IU1-47 | IU1 47 | IU147

Proteasome/Ubiquitin

DUB

DUB

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670270-31-2

330.856

C19H23ClN2O

>98% (HPLC)

DMSO : 16.67 mg/mL 50.39 mM

CC1=CC(C(CN2CCCCC2)=O)=C(C)N1C3=CC=C(Cl)C=C3

1-(1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1yl)ethanone

(-20℃)

With Ice Pack

≥ 2 years