IU1-47 ( IU1-47; IU1 47; IU147 )

产品货号. M15562 CAS No. 670270-31-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

IU1-47
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM.
产品描述

IU1-47 is a potent, selective small-molecule inhibitor of USP14 with IC50 of 0.6 uM, shows 10-fold more potent over IU1 and retains specificity for USP14; accelerates the rate of degradation of wild-type tau, the pathological tau mutants P301L and P301S, and the A152T tau variant in primary neuronal cultures, a specific residue in tau, lysine 174, is critical for the IU1-47-mediated tau degradation by the proteasome; stimulates autophagic flux in primary neurons.
同义词

IU1-47; IU1 47; IU147
通路

Proteasome/Ubiquitin
靶点

DUB
受体

DUB
研究领域

——
适应症

——

CAS Number

670270-31-2
分子量

330.86
分子式

C19H23ClN2O
纯度

>98% (HPLC)
溶解度

DMSO : 16.67 mg/mL 50.39 mM
SMILES

CC1=CC(C(CN2CCCCC2)=O)=C(C)N1C3=CC=C(Cl)C=C3
化学全称

1-(1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl)-2-(piperidin-1yl)ethanone

1. Boselli M, et al. J Biol Chem. 2017 Nov 24;292(47):19209-19225.

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产品手册

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