021-51111890
购物车（）
sales@molnova.cn
ML-323
CAS No. 1572414-83-5
ML-323 ( ML323;ML 323 )
产品货号. M12245 CAS No. 1572414-83-5
A potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥421 | 有现货 |
|
| 10MG | ￥624 | 有现货 |
|
| 25MG | ￥826 | 有现货 |
|
| 50MG | ￥1280 | 有现货 |
|
| 100MG | ￥1936 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称ML-323
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述A potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM.
-
产品描述A potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM; displays >1,500-fold selectivity versus USP2, USP5, USP7, USP8, and USP46/UAF1; potentiates the cytotoxicity of cisplatin and increases endogenous monoubiquitination levels of both PCNA and FANCD2, two known cellular targets of USP1/UAF1; possesses a promising in vitro ADME profile.
-
同义词ML323;ML 323
-
通路Proteasome/Ubiquitin
-
靶点DUB
-
受体USP1-UAF1
-
研究领域Cancer
-
适应症——
化学信息
-
CAS Number1572414-83-5
-
分子量384.48
-
分子式C23H24N6
-
纯度>98% (HPLC)
-
溶解度DMSO: ≥ 49 mg/mL
-
SMILESCC1=CN=C(C2=CC=CC=C2C(C)C)N=C1NCC3=CC=C(N4N=NC=C4)C=C3
-
化学全称N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Liang Q, et al. Nat Chem Biol. 2014 Apr;10(4):298-304.
2. Dexheimer TS, et al. J Med Chem. 2014 Oct 9;57(19):8099-110.
3. Sourisseau T, et al. Cell Cycle. 2016;15(2):295-302. doi: 10.1080/15384101.2015.1120918.
2. Dexheimer TS, et al. J Med Chem. 2014 Oct 9;57(19):8099-110.
3. Sourisseau T, et al. Cell Cycle. 2016;15(2):295-302. doi: 10.1080/15384101.2015.1120918.
产品手册
关联产品
