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ML-323
CAS No. 1572414-83-5
ML-323 ( ML323;ML 323 )
产品货号. M12245 CAS No. 1572414-83-5
A potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥421 | 有现货 |
|
| 10MG | ￥624 | 有现货 |
|
| 25MG | ￥826 | 有现货 |
|
| 50MG | ￥1280 | 有现货 |
|
| 100MG | ￥1936 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ML-323
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM.
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产品描述A potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM; displays >1,500-fold selectivity versus USP2, USP5, USP7, USP8, and USP46/UAF1; potentiates the cytotoxicity of cisplatin and increases endogenous monoubiquitination levels of both PCNA and FANCD2, two known cellular targets of USP1/UAF1; possesses a promising in vitro ADME profile.
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同义词ML323;ML 323
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通路Proteasome/Ubiquitin
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靶点DUB
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受体USP1-UAF1
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研究领域Cancer
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适应症——
化学信息
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CAS Number1572414-83-5
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分子量384.48
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分子式C23H24N6
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 49 mg/mL
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SMILESCC1=CN=C(C2=CC=CC=C2C(C)C)N=C1NCC3=CC=C(N4N=NC=C4)C=C3
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化学全称N-(4-(1H-1,2,3-triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Liang Q, et al. Nat Chem Biol. 2014 Apr;10(4):298-304.
2. Dexheimer TS, et al. J Med Chem. 2014 Oct 9;57(19):8099-110.
3. Sourisseau T, et al. Cell Cycle. 2016;15(2):295-302. doi: 10.1080/15384101.2015.1120918.
2. Dexheimer TS, et al. J Med Chem. 2014 Oct 9;57(19):8099-110.
3. Sourisseau T, et al. Cell Cycle. 2016;15(2):295-302. doi: 10.1080/15384101.2015.1120918.
产品手册
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