MK8745

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MK-8745 是一种有效的选择性 Aurora A 抑制剂。

MK-8745 is a potent and selective Aurora A inhibitor.

MK-8745 induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. Exposure of p53 wild-type cells to MK-8745 results in the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression. 1 μM of MK-8745 exposure for 24 h induces cell cycle arrest in all NHL cells, with variable degrees of G2/M arrest. Z138C cells are highly sensitive to MK-8745 (1 μ M) treatment and induces an approximate 5.5-fold increase in the G2/M phase cell population by 96 h. MK-8745 treatment inhibits phosphorylation of Aurora-A in Granta 519 and Z138C cells, while Akata and JVM2 has no effect. MK-8745 specifically inhibits Aurora-A specific function. MK-8745 treatment leads to apoptotic cell death.

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Proteasome/Ubiquitin

DUB

Aurora A| Aurora B

Cancer

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885325-71-3

431.91

C20H19ClFN5OS

>98% (HPLC)

DMSO : ≥ 34 mg/mL; 78.72 mM

C1CN(CCN1Cc1nc(ccc1)Nc1nccs1)C(=O)c1c(c(ccc1)Cl)F

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(-20℃)

With Ice Pack

≥ 2 years