021-51111890
购物车（）
sales@molnova.cn
GNE-6640
CAS No. 2009273-67-8
GNE-6640 ( GNE 6640;GNE6640 )
产品货号. M13134 CAS No. 2009273-67-8
GNE-6640 (GNE6640) is a potent, selective USP7 inhibitor with IC50 of 0.75 uM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥753 | 有现货 |
|
| 5MG | ￥1256 | 有现货 |
|
| 10MG | ￥2130 | 有现货 |
|
| 25MG | ￥4560 | 有现货 |
|
| 50MG | ￥6577 | 有现货 |
|
| 100MG | ￥9153 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称GNE-6640
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述GNE-6640 (GNE6640) is a potent, selective USP7 inhibitor with IC50 of 0.75 uM.
-
产品描述GNE-6640 (GNE6640) is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM); promotes endogenous MDM2 ubiquitination, stabilized p53 and upregulated p21, induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors; decreased viability of 108 cell lines with IC50 <10 uM.
-
同义词GNE 6640;GNE6640
-
通路Proteasome/Ubiquitin
-
靶点DUB
-
受体DUB
-
研究领域——
-
适应症——
化学信息
-
CAS Number2009273-67-8
-
分子量330.39
-
分子式C20H18N4O
-
纯度>98% (HPLC)
-
溶解度10 mM in DMSO
-
SMILESOC1=CC=C(C2=C(CC)C(C3=CC4=C(NN=C4)C=C3)=CN=C2N)C=C1
-
化学全称4-[2-Amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridyl]phenol
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
产品手册
关联产品
-
P-50429
P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor.
-
P 22077
P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM, also inhibits the closely related USP47.
-
USP7-IN-4
(R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays.
