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GNE-6640
CAS No. 2009273-67-8
GNE-6640 ( GNE 6640;GNE6640 )
产品货号. M13134 CAS No. 2009273-67-8
GNE-6640 (GNE6640) is a potent, selective USP7 inhibitor with IC50 of 0.75 uM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥753 | 有现货 |
|
| 5MG | ￥1256 | 有现货 |
|
| 10MG | ￥2130 | 有现货 |
|
| 25MG | ￥4560 | 有现货 |
|
| 50MG | ￥6577 | 有现货 |
|
| 100MG | ￥9153 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GNE-6640
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GNE-6640 (GNE6640) is a potent, selective USP7 inhibitor with IC50 of 0.75 uM.
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产品描述GNE-6640 (GNE6640) is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM); promotes endogenous MDM2 ubiquitination, stabilized p53 and upregulated p21, induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors; decreased viability of 108 cell lines with IC50 <10 uM.
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同义词GNE 6640;GNE6640
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通路Proteasome/Ubiquitin
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靶点DUB
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受体DUB
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研究领域——
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适应症——
化学信息
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CAS Number2009273-67-8
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分子量330.39
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分子式C20H18N4O
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESOC1=CC=C(C2=C(CC)C(C3=CC4=C(NN=C4)C=C3)=CN=C2N)C=C1
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化学全称4-[2-Amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridyl]phenol
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册
关联产品
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USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 has anticancer effects.
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PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.
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STD1T
STD1T (USP2a inhibitor STD1T) is a hit-to-lead, small-molecule inhibitor of USP2a with IC50 of 3.3 uM in Ub-AMC assays.
