USP7-IN-4 ( R)-USP-IN-4;USP7 inhibitor 4 )

产品货号. M13500 CAS No. 2196243-57-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

USP7-IN-4
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

(R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays.
产品描述

(R)-USP-IN-4 is a highly potent, selective, allosteric USP7 inhibitor with IC50 of 6 nM in FP assays; also shows high potency in an alternative assay using the Ub-Rh110 substrate (IC50=1.5 nM) and Kd of 2.0 nM; displays high selectivuty against other DUBs, proteases and kinases; demonstrates highly potent target engagement in cells (EC50=49 nM), with no off-target activity against USP47, causes nongenotoxic stabilization of p53 and decreased levels of MDM2 in HCT116 cells.
同义词

R)-USP-IN-4;USP7 inhibitor 4
通路

Proteasome/Ubiquitin
靶点

DUB
受体

DUB
研究领域

——
适应症

——

CAS Number

2196243-57-7
分子量

514.63
分子式

C29H34N6O3
纯度

>98% (HPLC)
溶解度

10 mM in DMSO
SMILES

O=C1C2=NN(C)C(C3=CC=C(CN)C=C3)=C2N=CN1CC4(O)CCN(C(C[C@H](C5=CC=CC=C5)C)=O)CC4
化学全称

(R)-3-(4-(aminomethyl)phenyl)-6-((4-hydroxy-1-(3-phenylbutanoyl)piperidin-4-yl)methyl)-2-methyl-2,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

1. Gavory G, et al. Nat Chem Biol. 2018 Feb;14(2):118-125.

计算器

产品手册

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