P-50429
CAS No. 1247825-37-1
P-50429 ( P50429;P 50429 )
产品货号. M11001 CAS No. 1247825-37-1
P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor.
纯度: 98.80% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥1539 | 有现货 |
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5MG | ¥2811 | 有现货 |
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10MG | ¥4026 | 有现货 |
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25MG | ¥6423 | 有现货 |
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50MG | ¥9153 | 有现货 |
|
100MG | ¥12312 | 有现货 |
|
500MG | ¥24057 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称P-50429
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor.
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产品描述P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor with no inhibition for caspase 3, calpain 1, 20S proteasome and a panel of representative USPs; exhibits 20-fold more potent inhibition of USP7 compared with P22077 (IC50 0.42 versus 8.0 uM); destabilizes HDM2, increases p53 and the downstream target p21, inhibits the proliferation of HCT-116 cells.
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同义词P50429;P 50429
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通路Proteasome/Ubiquitin
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靶点DUB
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受体USP7;USP47
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研究领域Cancer
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适应症——
化学信息
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CAS Number1247825-37-1
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分子量484.40
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分子式C18H11Cl2N3O3S3
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纯度98.80% (HPLC)
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溶解度DMSO: ≥ 44 mg/mL
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SMILESO/C(C1=CC(C#N)=C(SC2=C(Cl)C=NC=C2Cl)S1)=N\C3=CC=C(S(=O)(C)=O)C=C3
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化学全称2-Thiophenecarboxamide, 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Weinstock J, et al. ACS Med Chem Lett. 2012 Sep 11;3(10):789-92.
2. Pozhidaeva A, et al. Cell Chem Biol. 2017 Oct 4. pii: S2451-9456(17)30330-6.
2. Pozhidaeva A, et al. Cell Chem Biol. 2017 Oct 4. pii: S2451-9456(17)30330-6.
产品手册
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