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P-50429

CAS No. 1247825-37-1

P-50429 ( P50429;P 50429 )

产品货号. M11001 CAS No. 1247825-37-1

P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor.

纯度: 98.80% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥1539 有现货
5MG ¥2811 有现货
10MG ¥4026 有现货
25MG ¥6423 有现货
50MG ¥9153 有现货
100MG ¥12312 有现货
500MG ¥24057 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    P-50429
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor.
  • 产品描述
    P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor with no inhibition for caspase 3, calpain 1, 20S proteasome and a panel of representative USPs; exhibits 20-fold more potent inhibition of USP7 compared with P22077 (IC50 0.42 versus 8.0 uM); destabilizes HDM2, increases p53 and the downstream target p21, inhibits the proliferation of HCT-116 cells.
  • 同义词
    P50429;P 50429
  • 通路
    Proteasome/Ubiquitin
  • 靶点
    DUB
  • 受体
    USP7;USP47
  • 研究领域
    Cancer
  • 适应症
    ——

化学信息

  • CAS Number
    1247825-37-1
  • 分子量
    484.40
  • 分子式
    C18H11Cl2N3O3S3
  • 纯度
    98.80% (HPLC)
  • 溶解度
    DMSO: ≥ 44 mg/mL
  • SMILES
    O/C(C1=CC(C#N)=C(SC2=C(Cl)C=NC=C2Cl)S1)=N\C3=CC=C(S(=O)(C)=O)C=C3
  • 化学全称
    2-Thiophenecarboxamide, 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Weinstock J, et al. ACS Med Chem Lett. 2012 Sep 11;3(10):789-92.
2. Pozhidaeva A, et al. Cell Chem Biol. 2017 Oct 4. pii: S2451-9456(17)30330-6.
产品手册
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