P-50429

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

P-50429 (P50429, P 50429) 是一种有效的、选择性的、共价去泛素酶 USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) 抑制剂。

P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor with no inhibition for caspase 3, calpain 1, 20S proteasome and a panel of representative USPs; exhibits 20-fold more potent inhibition of USP7 compared with P22077 (IC50 0.42 versus 8.0 uM); destabilizes HDM2, increases p53 and the downstream target p21, inhibits the proliferation of HCT-116 cells.

USP7/USP47 inhibitor (compound 14) is a selective inhibitor of USP7/USP47 with EC50s of 0.42 μM and 1 μM, respectively. USP7/USP47 inhibitor does not inhibit caspase 3, calpain 1, 20S proteasome, and a panel of representative USPs (USP2, USP5, USP8, USP21, and USP28; EC50 > 31.6 μM). USP7/USP47 inhibitor inhibits the growth of HCT-116 cells with an EC50 of 7.6 μM.

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P50429 | P 50429

Proteasome/Ubiquitin

DUB

USP7|USP47

Cancer

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1247825-37-1

484.3992

C18H11Cl2N3O3S3

>98% (HPLC)

DMSO: ≥ 44 mg/mL

O/C(C1=CC(C#N)=C(SC2=C(Cl)C=NC=C2Cl)S1)=N\C3=CC=C(S(=O)(C)=O)C=C3

2-Thiophenecarboxamide, 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-

(-20℃)

With Ice Pack

≥ 2 years