P-50429
CAS No. 1247825-37-1
P-50429 ( P50429;P 50429 )
产品货号. M11001 CAS No. 1247825-37-1
P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor.
纯度: 98.80% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥1539 | 有现货 |
|
5MG | ¥2811 | 有现货 |
|
10MG | ¥4026 | 有现货 |
|
25MG | ¥6423 | 有现货 |
|
50MG | ¥9153 | 有现货 |
|
100MG | ¥12312 | 有现货 |
|
500MG | ¥24057 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称P-50429
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor.
-
产品描述P-50429 (P50429, P 50429) is a potent, selective, covalent deubiquitinase USP7 (EC50=0.42 uM)/USP47 (EC50=1.0 uM) inhibitor with no inhibition for caspase 3, calpain 1, 20S proteasome and a panel of representative USPs; exhibits 20-fold more potent inhibition of USP7 compared with P22077 (IC50 0.42 versus 8.0 uM); destabilizes HDM2, increases p53 and the downstream target p21, inhibits the proliferation of HCT-116 cells.
-
同义词P50429;P 50429
-
通路Proteasome/Ubiquitin
-
靶点DUB
-
受体USP7;USP47
-
研究领域Cancer
-
适应症——
化学信息
-
CAS Number1247825-37-1
-
分子量484.40
-
分子式C18H11Cl2N3O3S3
-
纯度98.80% (HPLC)
-
溶解度DMSO: ≥ 44 mg/mL
-
SMILESO/C(C1=CC(C#N)=C(SC2=C(Cl)C=NC=C2Cl)S1)=N\C3=CC=C(S(=O)(C)=O)C=C3
-
化学全称2-Thiophenecarboxamide, 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Weinstock J, et al. ACS Med Chem Lett. 2012 Sep 11;3(10):789-92.
2. Pozhidaeva A, et al. Cell Chem Biol. 2017 Oct 4. pii: S2451-9456(17)30330-6.
2. Pozhidaeva A, et al. Cell Chem Biol. 2017 Oct 4. pii: S2451-9456(17)30330-6.
产品手册
关联产品
-
SJB3-019A
A novel potent ubiquitin-specific protease USP1 inhibitor with IC50 of 78.1 nM.
-
NSC632839
A small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases.
-
ML-323
A potent, selective, reversible inhibitor of the USP1/UAF1 deubiquitinase complex with IC50 of 76 nM.