GNE-6776 ( GNE6776;GNE 6776 )

产品货号. M13135 CAS No. 2009273-71-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GNE-6776
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM.
产品描述

GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM ; dislpalys selectivity over USP47 and USP5 (>200 uM); promotes endogenous MDM2 ubiquitination, stabilized p53 and upregulated p21, induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents; promotes on-target pathway modulation in human xenografts.
同义词

GNE6776;GNE 6776
通路

Proteasome/Ubiquitin
靶点

DUB
受体

USP7
研究领域

——
适应症

——

CAS Number

2009273-71-4
分子量

348.41
分子式

C20H20N4O2
纯度

>98% (HPLC)
溶解度

DMSO: ≥310 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

CCC1=C(C(=NC=C1C2=CN=C(C=C2)C(=O)NC)N)C3=CC=C(C=C3)O
化学全称

5-[6-Amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridyl]-N-methyl-pyridine-2carboxamide

1. Kategaya L, et al. Nature. 2017 Oct 26;550(7677):534-538.

计算器

产品手册

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GNE-6776

GNE-6776 is a novel potent, specific, non-covalent, orally bioavailable USP7 inhibitor with IC50 of 1.34 uM.
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